Brain transforms natural killer cells that exacerbate brain edema after intracerebral hemorrhage

Perihematomal edema (PHE) occurs within hours after intracerebral hemorrhage (ICH), leading to secondary injury manifested by impaired blood-brain barrier (BBB) integrity and destruction of adjacent tissue. To dissect the mechanisms underlying PHE formation, we profiled human and mouse perihematomal...

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Veröffentlicht in:	The Journal of experimental medicine 2020-12, Vol.217 (12)
Hauptverfasser:	Li, Zhiguo, Li, Minshu, Shi, Samuel X, Yao, Nan, Cheng, Xiaojing, Guo, Ai, Zhu, Zilong, Zhang, Xiaoan, Liu, Qiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - immunology Blood-Brain Barrier - drug effects Blood-Brain Barrier - pathology Brain - pathology Brain Edema - etiology Brain Edema - immunology Cerebral Hemorrhage - complications Cerebral Hemorrhage - immunology Chemokine CXCL2 - metabolism Disease Models, Animal Disease Progression Endothelial Cells - drug effects Endothelial Cells - pathology Female Humans Inflammation - pathology Killer Cells, Natural - drug effects Killer Cells, Natural - immunology Male Mice, Inbred C57BL Neuroinflammation Neuroscience Poly I-C - pharmacology Transcriptome - genetics
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