MicroRNA-17-5p regulates EMT by targeting vimentin in colorectal cancer

Background Epithelial–mesenchymal transition (EMT) is the most common cause of death in colorectal cancer (CRC). In this study, we investigated the functional roles of miRNA-17-5p in EMT of CRC cells. Methods In order to determine if miRNA-17-5p regulated EMT, the precursors and inhibitors of miR-17...

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Veröffentlicht in:	British journal of cancer 2020-09, Vol.123 (7), p.1123-1130
Hauptverfasser:	Kim, Tae Won, Lee, Yeo Song, Yun, Nak Hyeon, Shin, Chang Hoon, Hong, Hye Kyung, Kim, Hyeon Ho, Cho, Yong Beom
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated regions 631/67/1504/1885 631/67/322 Animals Argonaute 2 protein Biomedical and Life Sciences Biomedicine Cancer Research Cell adhesion & migration Cell Line, Tumor Cell migration Cell Movement Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology Drug Resistance Epidemiology Epithelial-Mesenchymal Transition Female Gene Expression Regulation, Neoplastic Humans Immunoprecipitation Mesenchyme Metastases Metastasis Mice Mice, Inbred BALB C MicroRNAs MicroRNAs - physiology miRNA Molecular Medicine mRNA Neoplasm Invasiveness Neoplasm Metastasis Oncology Overexpression Spleen Vimentin Vimentin - genetics
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