Gut microbiota profiles of autism spectrum disorder and attention deficit/hyperactivity disorder: A systematic literature review
Accumulating evidence has implicated an involvement of the gut-brain axis in autism spectrum disorder (ASD) and attention-deficit hyperactivity disorder (ADHD), however with highly diverse results. This systematic review aims to describe and evaluate studies investigating the gut microbiota composit...
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| Veröffentlicht in: | Gut microbes 2020-09, Vol.11 (5), p.1172-1187 |
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| creator | Bundgaard-Nielsen, Caspar Knudsen, Julie Leutscher, Peter D. C. Lauritsen, Marlene B. Nyegaard, Mette Hagstrøm, Søren Sørensen, Suzette |
| description | Accumulating evidence has implicated an involvement of the gut-brain axis in autism spectrum disorder (ASD) and attention-deficit hyperactivity disorder (ADHD), however with highly diverse results. This systematic review aims to describe and evaluate studies investigating the gut microbiota composition in individuals with ASD or ADHD and to evaluate if variations in gut microbiota are associated with these disorders.
Twenty-four articles were identified in a systematic literature search of PubMed and Embase up to July 22, 2019. They consisted of 20 studies investigating ASD and four studies investigating ADHD. For ASD, several studies agreed on an overall difference in β-diversity, although no consistent bacterial variation between all studies was reported. For ADHD, the results were more diverse, with no clear differences observed.
Several common characteristics in gut microbiota function were identified for ASD compared to controls. In contrast, highly heterogeneous results were reported for ADHD, and thus the association between gut microbiota composition and ADHD remains unclear. For both disorders, methodological differences hampered the comparison of studies. |
| doi_str_mv | 10.1080/19490976.2020.1748258 |
| format | Article |
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Twenty-four articles were identified in a systematic literature search of PubMed and Embase up to July 22, 2019. They consisted of 20 studies investigating ASD and four studies investigating ADHD. For ASD, several studies agreed on an overall difference in β-diversity, although no consistent bacterial variation between all studies was reported. For ADHD, the results were more diverse, with no clear differences observed.
Several common characteristics in gut microbiota function were identified for ASD compared to controls. In contrast, highly heterogeneous results were reported for ADHD, and thus the association between gut microbiota composition and ADHD remains unclear. For both disorders, methodological differences hampered the comparison of studies.</description><identifier>ISSN: 1949-0976</identifier><identifier>EISSN: 1949-0984</identifier><identifier>DOI: 10.1080/19490976.2020.1748258</identifier><identifier>PMID: 32329656</identifier><language>eng</language><publisher>United States: Taylor & Francis</publisher><subject>attention-deficit hyperactivity disorder ; Autism Spectrum Disorder ; gut-Brain axis ; microbiome ; microbiota ; neurodevelopmental disorders ; Review ; systematic Review</subject><ispartof>Gut microbes, 2020-09, Vol.11 (5), p.1172-1187</ispartof><rights>2020 The Author(s). Published with license by Taylor & Francis Group, LLC. 2020</rights><rights>2020 The Author(s). Published with license by Taylor & Francis Group, LLC. 2020 The Author(s)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c534t-5919d8ae3be3f772f41feff978683a010b0f833cf760b0139167f86974e77af53</citedby><cites>FETCH-LOGICAL-c534t-5919d8ae3be3f772f41feff978683a010b0f833cf760b0139167f86974e77af53</cites><orcidid>0000-0002-5528-3592 ; 0000-0002-1217-808X ; 0000-0003-1168-4041 ; 0000-0002-4201-1168 ; 0000-0002-2700-2378 ; 0000-0001-7284-9255 ; 0000-0003-4973-8543</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7524304/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7524304/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32329656$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bundgaard-Nielsen, Caspar</creatorcontrib><creatorcontrib>Knudsen, Julie</creatorcontrib><creatorcontrib>Leutscher, Peter D. C.</creatorcontrib><creatorcontrib>Lauritsen, Marlene B.</creatorcontrib><creatorcontrib>Nyegaard, Mette</creatorcontrib><creatorcontrib>Hagstrøm, Søren</creatorcontrib><creatorcontrib>Sørensen, Suzette</creatorcontrib><title>Gut microbiota profiles of autism spectrum disorder and attention deficit/hyperactivity disorder: A systematic literature review</title><title>Gut microbes</title><addtitle>Gut Microbes</addtitle><description>Accumulating evidence has implicated an involvement of the gut-brain axis in autism spectrum disorder (ASD) and attention-deficit hyperactivity disorder (ADHD), however with highly diverse results. This systematic review aims to describe and evaluate studies investigating the gut microbiota composition in individuals with ASD or ADHD and to evaluate if variations in gut microbiota are associated with these disorders.
Twenty-four articles were identified in a systematic literature search of PubMed and Embase up to July 22, 2019. They consisted of 20 studies investigating ASD and four studies investigating ADHD. For ASD, several studies agreed on an overall difference in β-diversity, although no consistent bacterial variation between all studies was reported. For ADHD, the results were more diverse, with no clear differences observed.
Several common characteristics in gut microbiota function were identified for ASD compared to controls. In contrast, highly heterogeneous results were reported for ADHD, and thus the association between gut microbiota composition and ADHD remains unclear. 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C.</creatorcontrib><creatorcontrib>Lauritsen, Marlene B.</creatorcontrib><creatorcontrib>Nyegaard, Mette</creatorcontrib><creatorcontrib>Hagstrøm, Søren</creatorcontrib><creatorcontrib>Sørensen, Suzette</creatorcontrib><collection>Taylor & Francis Open Access Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Gut microbes</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bundgaard-Nielsen, Caspar</au><au>Knudsen, Julie</au><au>Leutscher, Peter D. 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This systematic review aims to describe and evaluate studies investigating the gut microbiota composition in individuals with ASD or ADHD and to evaluate if variations in gut microbiota are associated with these disorders.
Twenty-four articles were identified in a systematic literature search of PubMed and Embase up to July 22, 2019. They consisted of 20 studies investigating ASD and four studies investigating ADHD. For ASD, several studies agreed on an overall difference in β-diversity, although no consistent bacterial variation between all studies was reported. For ADHD, the results were more diverse, with no clear differences observed.
Several common characteristics in gut microbiota function were identified for ASD compared to controls. In contrast, highly heterogeneous results were reported for ADHD, and thus the association between gut microbiota composition and ADHD remains unclear. For both disorders, methodological differences hampered the comparison of studies.</abstract><cop>United States</cop><pub>Taylor & Francis</pub><pmid>32329656</pmid><doi>10.1080/19490976.2020.1748258</doi><tpages>16</tpages><orcidid>https://orcid.org/0000-0002-5528-3592</orcidid><orcidid>https://orcid.org/0000-0002-1217-808X</orcidid><orcidid>https://orcid.org/0000-0003-1168-4041</orcidid><orcidid>https://orcid.org/0000-0002-4201-1168</orcidid><orcidid>https://orcid.org/0000-0002-2700-2378</orcidid><orcidid>https://orcid.org/0000-0001-7284-9255</orcidid><orcidid>https://orcid.org/0000-0003-4973-8543</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | attention-deficit hyperactivity disorder Autism Spectrum Disorder gut-Brain axis microbiome microbiota neurodevelopmental disorders Review systematic Review |
| title | Gut microbiota profiles of autism spectrum disorder and attention deficit/hyperactivity disorder: A systematic literature review |
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