Histone modifications silence the GATA transcription factor genes in ovarian cancer
Altered expression of GATA factors was found and proposed as the underlying mechanism for dedifferentiation in ovarian carcinogenesis. In particular, GATA6 is lost or excluded from the nucleus in 85% of ovarian tumors and GATA4 expression is absent in majority of ovarian cancer cell lines. Here, we...
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| Veröffentlicht in: | Oncogene 2006-08, Vol.25 (39), p.5446-5461 |
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| creator | Caslini, C Capo-chichi, C D Roland, I H Nicolas, E Yeung, A T Xu, X-X |
| description | Altered expression of GATA factors was found and proposed as the underlying mechanism for dedifferentiation in ovarian carcinogenesis. In particular, GATA6 is lost or excluded from the nucleus in 85% of ovarian tumors and GATA4 expression is absent in majority of ovarian cancer cell lines. Here, we evaluated their DNA and histone epigenetic modifications in five ovarian epithelial and carcinoma cell lines (human ‘immortalized’ ovarian surface epithelium (HIO)-117, HIO-114, A2780, SKOV3 and ES2). GATA4 and GATA6 gene silencing was found to correlate with hypoacetylation of histones H3 and H4 and loss of histone H3/lysine K4 tri-methylation at their promoters in all lines. Conversely, histone H3/lysine K9 di-methylation and HP1
γ
association were not observed, excluding reorganization of GATA genes into heterochromatic structures. The histone deacetylase inhibitor trichostatin A, but not the DNA methylation inhibitor 5′-aza-2′-deoxycytidine, re-established the expression of GATA4 and/or GATA6 in A2780 and HIO-114 cells, correlating with increased histone H3 and H4 acetylation, histone H3 lysine K4 methylation and DNase I sensitivity at the promoters. Therefore, altered histone modification of the promoter loci is one mechanism responsible for the silencing of GATA transcription factors and the subsequent loss of a target gene, the tumor suppressor Disabled-2, in ovarian carcinogenesis. |
| doi_str_mv | 10.1038/sj.onc.1209533 |
| format | Article |
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γ
association were not observed, excluding reorganization of GATA genes into heterochromatic structures. The histone deacetylase inhibitor trichostatin A, but not the DNA methylation inhibitor 5′-aza-2′-deoxycytidine, re-established the expression of GATA4 and/or GATA6 in A2780 and HIO-114 cells, correlating with increased histone H3 and H4 acetylation, histone H3 lysine K4 methylation and DNase I sensitivity at the promoters. Therefore, altered histone modification of the promoter loci is one mechanism responsible for the silencing of GATA transcription factors and the subsequent loss of a target gene, the tumor suppressor Disabled-2, in ovarian carcinogenesis.</description><identifier>ISSN: 0950-9232</identifier><identifier>EISSN: 1476-5594</identifier><identifier>DOI: 10.1038/sj.onc.1209533</identifier><identifier>PMID: 16607277</identifier><identifier>CODEN: ONCNES</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Acetylation ; Adaptor Proteins, Signal Transducing - genetics ; Apoptosis ; Biological and medical sciences ; Carcinogenesis ; Carcinoma ; Cell Biology ; Cell Line, Tumor ; Cell physiology ; Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes ; Chromatin. Chromosome ; Deoxyribonuclease ; DNA methylation ; Epigenetics ; Epithelium ; Female ; Female genital diseases ; Fundamental and applied biological sciences. Psychology ; GATA Transcription Factors - genetics ; GATA4 Transcription Factor - genetics ; Gata6 gene ; GATA6 Transcription Factor - genetics ; Gene expression ; Gene Silencing ; Genes ; Genes, Tumor Suppressor ; Genetics ; Gynecology. Andrology. Obstetrics ; Heterochromatin - genetics ; Histone deacetylase ; Histone H3 ; Histones - metabolism ; Human Genetics ; Humans ; Internal Medicine ; Lysine ; Medical sciences ; Medicine ; Medicine & Public Health ; Methylation ; Molecular and cellular biology ; Molecular genetics ; Oncology ; original-article ; Ovarian cancer ; Ovarian Neoplasms - genetics ; Transcription factors ; Trichostatin A ; Tumor cell lines ; Tumor suppressor genes ; Tumor Suppressor Proteins ; Tumors</subject><ispartof>Oncogene, 2006-08, Vol.25 (39), p.5446-5461</ispartof><rights>Springer Nature Limited 2006</rights><rights>2006 INIST-CNRS</rights><rights>COPYRIGHT 2006 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Aug 31, 2006</rights><rights>Nature Publishing Group 2006.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c680t-5b479bd0cc2240df421af5b07782d574f049eb7b2bd23e26cffa72190f0c77393</citedby><cites>FETCH-LOGICAL-c680t-5b479bd0cc2240df421af5b07782d574f049eb7b2bd23e26cffa72190f0c77393</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/sj.onc.1209533$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/sj.onc.1209533$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18087388$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16607277$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Caslini, C</creatorcontrib><creatorcontrib>Capo-chichi, C D</creatorcontrib><creatorcontrib>Roland, I H</creatorcontrib><creatorcontrib>Nicolas, E</creatorcontrib><creatorcontrib>Yeung, A T</creatorcontrib><creatorcontrib>Xu, X-X</creatorcontrib><title>Histone modifications silence the GATA transcription factor genes in ovarian cancer</title><title>Oncogene</title><addtitle>Oncogene</addtitle><addtitle>Oncogene</addtitle><description>Altered expression of GATA factors was found and proposed as the underlying mechanism for dedifferentiation in ovarian carcinogenesis. In particular, GATA6 is lost or excluded from the nucleus in 85% of ovarian tumors and GATA4 expression is absent in majority of ovarian cancer cell lines. Here, we evaluated their DNA and histone epigenetic modifications in five ovarian epithelial and carcinoma cell lines (human ‘immortalized’ ovarian surface epithelium (HIO)-117, HIO-114, A2780, SKOV3 and ES2). GATA4 and GATA6 gene silencing was found to correlate with hypoacetylation of histones H3 and H4 and loss of histone H3/lysine K4 tri-methylation at their promoters in all lines. Conversely, histone H3/lysine K9 di-methylation and HP1
γ
association were not observed, excluding reorganization of GATA genes into heterochromatic structures. The histone deacetylase inhibitor trichostatin A, but not the DNA methylation inhibitor 5′-aza-2′-deoxycytidine, re-established the expression of GATA4 and/or GATA6 in A2780 and HIO-114 cells, correlating with increased histone H3 and H4 acetylation, histone H3 lysine K4 methylation and DNase I sensitivity at the promoters. Therefore, altered histone modification of the promoter loci is one mechanism responsible for the silencing of GATA transcription factors and the subsequent loss of a target gene, the tumor suppressor Disabled-2, in ovarian carcinogenesis.</description><subject>Acetylation</subject><subject>Adaptor Proteins, Signal Transducing - genetics</subject><subject>Apoptosis</subject><subject>Biological and medical sciences</subject><subject>Carcinogenesis</subject><subject>Carcinoma</subject><subject>Cell Biology</subject><subject>Cell Line, Tumor</subject><subject>Cell physiology</subject><subject>Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes</subject><subject>Chromatin. Chromosome</subject><subject>Deoxyribonuclease</subject><subject>DNA methylation</subject><subject>Epigenetics</subject><subject>Epithelium</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>GATA Transcription Factors - genetics</subject><subject>GATA4 Transcription Factor - genetics</subject><subject>Gata6 gene</subject><subject>GATA6 Transcription Factor - genetics</subject><subject>Gene expression</subject><subject>Gene Silencing</subject><subject>Genes</subject><subject>Genes, Tumor Suppressor</subject><subject>Genetics</subject><subject>Gynecology. Andrology. 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In particular, GATA6 is lost or excluded from the nucleus in 85% of ovarian tumors and GATA4 expression is absent in majority of ovarian cancer cell lines. Here, we evaluated their DNA and histone epigenetic modifications in five ovarian epithelial and carcinoma cell lines (human ‘immortalized’ ovarian surface epithelium (HIO)-117, HIO-114, A2780, SKOV3 and ES2). GATA4 and GATA6 gene silencing was found to correlate with hypoacetylation of histones H3 and H4 and loss of histone H3/lysine K4 tri-methylation at their promoters in all lines. Conversely, histone H3/lysine K9 di-methylation and HP1
γ
association were not observed, excluding reorganization of GATA genes into heterochromatic structures. The histone deacetylase inhibitor trichostatin A, but not the DNA methylation inhibitor 5′-aza-2′-deoxycytidine, re-established the expression of GATA4 and/or GATA6 in A2780 and HIO-114 cells, correlating with increased histone H3 and H4 acetylation, histone H3 lysine K4 methylation and DNase I sensitivity at the promoters. Therefore, altered histone modification of the promoter loci is one mechanism responsible for the silencing of GATA transcription factors and the subsequent loss of a target gene, the tumor suppressor Disabled-2, in ovarian carcinogenesis.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>16607277</pmid><doi>10.1038/sj.onc.1209533</doi><tpages>16</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acetylation Adaptor Proteins, Signal Transducing - genetics Apoptosis Biological and medical sciences Carcinogenesis Carcinoma Cell Biology Cell Line, Tumor Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Chromatin. Chromosome Deoxyribonuclease DNA methylation Epigenetics Epithelium Female Female genital diseases Fundamental and applied biological sciences. Psychology GATA Transcription Factors - genetics GATA4 Transcription Factor - genetics Gata6 gene GATA6 Transcription Factor - genetics Gene expression Gene Silencing Genes Genes, Tumor Suppressor Genetics Gynecology. Andrology. Obstetrics Heterochromatin - genetics Histone deacetylase Histone H3 Histones - metabolism Human Genetics Humans Internal Medicine Lysine Medical sciences Medicine Medicine & Public Health Methylation Molecular and cellular biology Molecular genetics Oncology original-article Ovarian cancer Ovarian Neoplasms - genetics Transcription factors Trichostatin A Tumor cell lines Tumor suppressor genes Tumor Suppressor Proteins Tumors |
| title | Histone modifications silence the GATA transcription factor genes in ovarian cancer |
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