Ablation of conceptus PTGS2 expression does not alter early conceptus development and establishment of pregnancy in the pig

Pig conceptuses secrete estrogens (E2), interleukin 1 beta 2 (IL1B2), and prostaglandins (PGs) during the period of rapid trophoblast elongation and establishment of pregnancy. Previous studies established that IL1B2 is essential for rapid conceptus elongation, whereas E2 is not essential for concep...

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Veröffentlicht in:	Biology of reproduction 2020-02, Vol.102 (2), p.475-488
Hauptverfasser:	Pfeiffer, Caroline A, Meyer, Ashley E, Brooks, Kelsey E, Chen, Paula R, Milano-Foster, Jessica, Spate, Lee D, Benne, Joshua A, Cecil, Raissa F, Samuel, Melissa S, Ciernia, Lauren A, Spinka, Christine M, Smith, Michael F, Wells, Kevin D, Spencer, Thomas E, Prather, Randall S, Geisert, Rodney D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal reproduction Animal sciences conceptus CRISPR CRISPR-Cas systems Cyclooxygenases Cytokines early development Embryos Enzymes Fibroblasts Health aspects Hogs implantation interleukin-1 Laboratory animals loss-of-function mutation Physiological aspects pig Pregnancy prostaglandin synthase prostaglandins PTGS2 Reproductive health RESEARCH ARTICLE somatic cells Swine trophoblast uterus
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