Structural and functional modelling of SARS-CoV-2 entry in animal models

SARS-CoV-2 is the novel coronavirus responsible for the outbreak of COVID-19, a disease that has spread to over 100 countries and, as of the 26th July 2020, has infected over 16 million people. Despite the urgent need to find effective therapeutics, research on SARS-CoV-2 has been affected by a lack...

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Veröffentlicht in:	Scientific reports 2020-09, Vol.10 (1), p.15917-15917, Article 15917
Hauptverfasser:	Brooke, Greg N., Prischi, Filippo
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/255/2514 631/45/612/1256 631/535/1267 Amino Acid Sequence - genetics Angiotensin-Converting Enzyme 2 Animals Betacoronavirus - genetics Cats Computational Biology - methods Coronavirus Infections - pathology Coronavirus Infections - veterinary COVID-19 Cricetinae Disease Models, Animal Dogs Ferrets Furin - genetics Furin - metabolism Guinea Pigs Humanities and Social Sciences Humans Macaca fascicularis Mice Molecular Docking Simulation multidisciplinary Pandemics - veterinary Peptidyl-Dipeptidase A - genetics Peptidyl-Dipeptidase A - metabolism Pneumonia, Viral - pathology Pneumonia, Viral - veterinary Rabbits Rats SARS-CoV-2 Science Science (multidisciplinary) Serine Endopeptidases - genetics Serine Endopeptidases - metabolism Spike Glycoprotein, Coronavirus - genetics Spike Glycoprotein, Coronavirus - metabolism
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