Skin α-Synuclein Aggregation Seeding Activity as a Novel Biomarker for Parkinson Disease

IMPORTANCE: Deposition of the pathological α-synuclein (αSynP) in the brain is the hallmark of synucleinopathies, including Parkinson disease (PD), Lewy body dementia (LBD), and multiple system atrophy (MSA). Whether real-time quaking-induced conversion (RT-QuIC) and protein misfolding cyclic amplif...

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Veröffentlicht in:	Archives of neurology (Chicago) 2021-01, Vol.78 (1), p.30-40
Hauptverfasser:	Wang, Zerui, Becker, Katelyn, Donadio, Vincenzo, Siedlak, Sandra, Yuan, Jue, Rezaee, Masih, Incensi, Alex, Kuzkina, Anastasia, Orrú, Christina D, Tatsuoka, Curtis, Liguori, Rocco, Gunzler, Steven A, Caughey, Byron, Jimenez-Capdeville, Maria E, Zhu, Xiongwei, Doppler, Kathrin, Cui, Li, Chen, Shu G, Ma, Jiyan, Zou, Wen-Quan
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Atrophy Autopsies Autopsy Biomarkers Biopsy Cadavers Comments Degeneration Dementia disorders Diagnosis Diagnostic systems Health care facilities Lewy bodies Movement disorders Neurodegeneration Neurodegenerative diseases Online First Original Investigation Paralysis Parkinson's disease Patients Progressive supranuclear palsy Protein folding Protein seeding Sensitivity Skin Synuclein
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