The transcription factor PITX1 drives astrocyte differentiation by regulating the SOX9 gene

Astrocytes perform multiple essential functions in the developing and mature brain, including regulation of synapse formation, control of neurotransmitter release and uptake, and maintenance of extracellular ion balance. As a result, astrocytes have been implicated in the progression of neurodegener...

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Veröffentlicht in:	The Journal of biological chemistry 2020-09, Vol.295 (39), p.13677-13690
Hauptverfasser:	Byun, Jeong Su, Oh, Mihee, Lee, Seonha, Gil, Jung-Eun, Mo, Yeajin, Ku, Bonsu, Kim, Won-Kon, Oh, Kyoung-Jin, Lee, Eun-Woo, Bae, Kwang-Hee, Lee, Sang Chul, Han, Baek-Soo
Format:	Artikel
Sprache:	eng
Schlagworte:	astrocyte Astrocytes - metabolism Cell Differentiation Cells, Cultured Developmental Biology glial cell gliogenesis human embryonic stem cell Humans neural stem cell (NSC) Paired Box Transcription Factors - genetics Paired Box Transcription Factors - metabolism paired-like homeodomain transcription factor 1 (PITX1) sex-determining region Y box 9 (SOX9) SOX9 Transcription Factor - genetics SOX9 Transcription Factor - metabolism transcription factor
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