Evaluation of the pharmacokinetic drug-drug interaction potential of iohexol, a renal filtration marker

Purpose Carboplatin dose is calculated based on kidney function, commonly estimated with imperfect creatinine-based formulae. Iohexol is used to measure glomerular filtration rate (GFR) and allows calculation of a more appropriate carboplatin dose. To address potential concerns that iohexol administ...

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Veröffentlicht in:	Cancer chemotherapy and pharmacology 2020-10, Vol.86 (4), p.535-545
Hauptverfasser:	Joshi, Anand, Guo, Jianxia, Holleran, Julianne L., Kiesel, Brian, Taylor, Sarah, Christner, Susan, Parise, Robert A., Miller, Brian M., Ivy, S. Percy, Chu, Edward, Venkataramanan, Raman, Beumer, Jan H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intravenous Animals Antineoplastic Combined Chemotherapy Protocols - administration & dosage Antineoplastic Combined Chemotherapy Protocols - pharmacokinetics Area Under Curve Bone Marrow - chemistry Cancer Research Carboplatin - administration & dosage Carboplatin - pharmacokinetics Contrast Media - administration & dosage Contrast Media - pharmacokinetics Creatinine Cytochrome P-450 Enzyme System - metabolism Deoxycytidine - administration & dosage Deoxycytidine - analogs & derivatives Deoxycytidine - pharmacokinetics Drug Dosage Calculations Drug Interactions Female Glomerular Filtration Rate Glucuronosyltransferase - metabolism Humans Iohexol - administration & dosage Iohexol - pharmacokinetics Kidney - chemistry Kidney - metabolism Medicine Medicine & Public Health Metabolic Clearance Rate Mice Microsomes, Liver Models, Animal Oncology Original Article Paclitaxel - administration & dosage Paclitaxel - pharmacokinetics Pharmacology/Toxicology Specific Pathogen-Free Organisms Tandem Mass Spectrometry Tissue Distribution
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