Glucosamine protects against radiation‐induced lung injury via inhibition of epithelial‐mesenchymal transition
Radiotherapy is one of the most important treatments for chest tumours. Although there are plenty of strategies to prevent damage to normal lung tissues, it cannot be avoided with the emergence of radiation‐induced lung injury. The purpose of this study was to investigate the potential radioprotecti...
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| Veröffentlicht in: | Journal of cellular and molecular medicine 2020-09, Vol.24 (18), p.11018-11023 |
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| container_title | Journal of cellular and molecular medicine |
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| creator | Lei, Xiao Ma, Na Liang, Yanjie Liu, Junyan Zhang, Pei Han, Yanan Chen, Wei Du, Lehui Qu, Baolin |
| description | Radiotherapy is one of the most important treatments for chest tumours. Although there are plenty of strategies to prevent damage to normal lung tissues, it cannot be avoided with the emergence of radiation‐induced lung injury. The purpose of this study was to investigate the potential radioprotective effects of glucosamine, which exerted anti‐inflammatory activity in joint inflammation. In this study, we found glucosamine relieved inflammatory response and structural damages in lung tissues after radiation via HE staining. Then, we detected the level of epithelial‐mesenchymal transition marker in vitro and in vivo, which we could clearly observe that glucosamine treatment inhibited epithelial‐mesenchymal transition. Besides, we found glucosamine could inhibit apoptosis and promote proliferation of normal lung epithelial cells in vitro caused by radiation. In conclusion, our data showed that glucosamine alleviated radiation‐induced lung injury via inhibiting epithelial‐mesenchymal transition, which indicated glucosamine could be a novel potential radioprotector for radiation‐induced lung injury. |
| doi_str_mv | 10.1111/jcmm.15662 |
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Although there are plenty of strategies to prevent damage to normal lung tissues, it cannot be avoided with the emergence of radiation‐induced lung injury. The purpose of this study was to investigate the potential radioprotective effects of glucosamine, which exerted anti‐inflammatory activity in joint inflammation. In this study, we found glucosamine relieved inflammatory response and structural damages in lung tissues after radiation via HE staining. Then, we detected the level of epithelial‐mesenchymal transition marker in vitro and in vivo, which we could clearly observe that glucosamine treatment inhibited epithelial‐mesenchymal transition. Besides, we found glucosamine could inhibit apoptosis and promote proliferation of normal lung epithelial cells in vitro caused by radiation. In conclusion, our data showed that glucosamine alleviated radiation‐induced lung injury via inhibiting epithelial‐mesenchymal transition, which indicated glucosamine could be a novel potential radioprotector for radiation‐induced lung injury.</description><identifier>ISSN: 1582-1838</identifier><identifier>EISSN: 1582-4934</identifier><identifier>DOI: 10.1111/jcmm.15662</identifier><identifier>PMID: 32700471</identifier><language>eng</language><publisher>England: John Wiley & Sons, Inc</publisher><subject>Anti-inflammatory agents ; Apoptosis ; Cartilage ; Cell proliferation ; Cells ; Drug dosages ; EMT ; Epithelial cells ; Fibroblasts ; Glucosamine ; Inflammation ; Laboratory animals ; lung tissues ; Lungs ; Medical prognosis ; Medical research ; Mesenchyme ; radiation ; Radiation therapy ; Short Communication ; Short Communications ; Tumors</subject><ispartof>Journal of cellular and molecular medicine, 2020-09, Vol.24 (18), p.11018-11023</ispartof><rights>2020 The Authors. published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.</rights><rights>2020 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.</rights><rights>2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5422-a88af93fe81e86f98459d725a543b61c93ca6215e8d17a7398103c84176f9f213</citedby><cites>FETCH-LOGICAL-c5422-a88af93fe81e86f98459d725a543b61c93ca6215e8d17a7398103c84176f9f213</cites><orcidid>0000-0002-3297-899X ; 0000-0002-0428-1749</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521322/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521322/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,1411,11542,27903,27904,45553,45554,46031,46455,53770,53772</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32700471$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lei, Xiao</creatorcontrib><creatorcontrib>Ma, Na</creatorcontrib><creatorcontrib>Liang, Yanjie</creatorcontrib><creatorcontrib>Liu, Junyan</creatorcontrib><creatorcontrib>Zhang, Pei</creatorcontrib><creatorcontrib>Han, Yanan</creatorcontrib><creatorcontrib>Chen, Wei</creatorcontrib><creatorcontrib>Du, Lehui</creatorcontrib><creatorcontrib>Qu, Baolin</creatorcontrib><title>Glucosamine protects against radiation‐induced lung injury via inhibition of epithelial‐mesenchymal transition</title><title>Journal of cellular and molecular medicine</title><addtitle>J Cell Mol Med</addtitle><description>Radiotherapy is one of the most important treatments for chest tumours. Although there are plenty of strategies to prevent damage to normal lung tissues, it cannot be avoided with the emergence of radiation‐induced lung injury. The purpose of this study was to investigate the potential radioprotective effects of glucosamine, which exerted anti‐inflammatory activity in joint inflammation. In this study, we found glucosamine relieved inflammatory response and structural damages in lung tissues after radiation via HE staining. Then, we detected the level of epithelial‐mesenchymal transition marker in vitro and in vivo, which we could clearly observe that glucosamine treatment inhibited epithelial‐mesenchymal transition. Besides, we found glucosamine could inhibit apoptosis and promote proliferation of normal lung epithelial cells in vitro caused by radiation. In conclusion, our data showed that glucosamine alleviated radiation‐induced lung injury via inhibiting epithelial‐mesenchymal transition, which indicated glucosamine could be a novel potential radioprotector for radiation‐induced lung injury.</description><subject>Anti-inflammatory agents</subject><subject>Apoptosis</subject><subject>Cartilage</subject><subject>Cell proliferation</subject><subject>Cells</subject><subject>Drug dosages</subject><subject>EMT</subject><subject>Epithelial cells</subject><subject>Fibroblasts</subject><subject>Glucosamine</subject><subject>Inflammation</subject><subject>Laboratory animals</subject><subject>lung tissues</subject><subject>Lungs</subject><subject>Medical prognosis</subject><subject>Medical research</subject><subject>Mesenchyme</subject><subject>radiation</subject><subject>Radiation therapy</subject><subject>Short Communication</subject><subject>Short Communications</subject><subject>Tumors</subject><issn>1582-1838</issn><issn>1582-4934</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kc9uEzEQhy0EoqVw4QHQSlwQUlr_t_eCVEVQqFpxgbM18XoTR1472LtFufEIPCNPgtOkFfRQXzzSfPNpRj-EXhN8Suo7W9thOCVCSvoEHROh6Yy3jD891EQzfYRelLLGmEnC2ufoiFGFMVfkGOWLMNlUYPDRNZucRmfH0sASfCxjk6HzMPoU__z67WM3Wdc1YYrLxsf1lLfNjYdarvzC76Am9Y3b-HHlgodQRwZXXLSr7QChGTPEcou9RM96CMW9Ovwn6Punj9_mn2dXXy--zM-vZlZwSmegNfQt650mTsu-1Vy0naICBGcLSWzLLEhKhNMdUaBYqwlmVnOiKtxTwk7Qh713My0G11kX6w7BbLIfIG9NAm_-70S_Mst0Y5So05RWwbuDIKcfkyujGXyxLgSILk3FUE6lYFpiXdG3D9B1mnKs5xmqFBOcK64epTiXklFMd9T7PWVzKiW7_n5lgs0ucLML3NwGXuE3_x55j94lXAGyB3764LaPqMzl_Pp6L_0LXrK5jg</recordid><startdate>202009</startdate><enddate>202009</enddate><creator>Lei, Xiao</creator><creator>Ma, Na</creator><creator>Liang, Yanjie</creator><creator>Liu, Junyan</creator><creator>Zhang, Pei</creator><creator>Han, Yanan</creator><creator>Chen, Wei</creator><creator>Du, Lehui</creator><creator>Qu, Baolin</creator><general>John Wiley & Sons, Inc</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>WIN</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-3297-899X</orcidid><orcidid>https://orcid.org/0000-0002-0428-1749</orcidid></search><sort><creationdate>202009</creationdate><title>Glucosamine protects against radiation‐induced lung injury via inhibition of epithelial‐mesenchymal transition</title><author>Lei, Xiao ; 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Although there are plenty of strategies to prevent damage to normal lung tissues, it cannot be avoided with the emergence of radiation‐induced lung injury. The purpose of this study was to investigate the potential radioprotective effects of glucosamine, which exerted anti‐inflammatory activity in joint inflammation. In this study, we found glucosamine relieved inflammatory response and structural damages in lung tissues after radiation via HE staining. Then, we detected the level of epithelial‐mesenchymal transition marker in vitro and in vivo, which we could clearly observe that glucosamine treatment inhibited epithelial‐mesenchymal transition. Besides, we found glucosamine could inhibit apoptosis and promote proliferation of normal lung epithelial cells in vitro caused by radiation. 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| subjects | Anti-inflammatory agents Apoptosis Cartilage Cell proliferation Cells Drug dosages EMT Epithelial cells Fibroblasts Glucosamine Inflammation Laboratory animals lung tissues Lungs Medical prognosis Medical research Mesenchyme radiation Radiation therapy Short Communication Short Communications Tumors |
| title | Glucosamine protects against radiation‐induced lung injury via inhibition of epithelial‐mesenchymal transition |
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