Chronopharmacology of simvastatin on hyperlipidaemia in high‐fat diet‐fed obese mice

The chronopharmacology refers to the utilization of physiological circadian rhythms to optimize the administration time of drugs, thus increasing their efficacy and safety, or reducing adverse effects. Simvastatin is one of the most widely prescribed drugs for the treatment of hypercholesterolaemia,...

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Veröffentlicht in:	Journal of cellular and molecular medicine 2020-09, Vol.24 (18), p.11024-11029
Hauptverfasser:	Li, Huan, Rabearivony, Anjara, Zhang, Wenxiang, Chen, Siyu, An, Xiaofei, Liu, Chang
Format:	Artikel
Sprache:	eng
Schlagworte:	BMAL1 protein Cholesterol chronopharmacology Circadian rhythm Circadian rhythms Clock gene Coronary artery Coronary artery disease Diet Drugs Fatty acids Heart diseases High fat diet hypercholesterolaemia Hypercholesterolemia Hyperlipidemia Lipids Liver Low density lipoprotein MDR1 protein Metabolism Period 2 protein Serum levels Short Communication Short Communications Simvastatin Triglycerides
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