Corilagin suppresses RANKL‐induced osteoclastogenesis and inhibits oestrogen deficiency‐induced bone loss via the NF‐κB and PI3K/AKT signalling pathways

Over‐activated osteoclastogenesis, which is initiated by inflammation, has been implicated in osteoporosis. Corilagin, a natural compound extracted from various medicinal herbaceous plants, such as Cinnamomum cassia, has antioxidant and anti‐inflammatory activities. We found that Corilagin suppresse...

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Veröffentlicht in:	Journal of cellular and molecular medicine 2020-09, Vol.24 (18), p.10444-10457
Hauptverfasser:	Lu, Jinwei, Ye, Chenyi, Huang, Yanyong, Huang, Donghui, Tang, Lan, Hou, Weiduo, Kuang, Zhihui, Chen, Yazhou, Xiao, Shining, Yishake, Mumingjiang, He, Rongxin
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Actins - metabolism AKT protein Animal models Animals Antibodies Antioxidants Bone loss Bone Marrow Cells - drug effects Bone Marrow Cells - metabolism Bone resorption Bone Resorption - pathology Corilagin Down-Regulation - drug effects Estrogens Estrogens - deficiency Gene expression Glucosides - chemistry Glucosides - pharmacology Hydrolyzable Tannins - chemistry Hydrolyzable Tannins - pharmacology Inflammation Laboratory animals Medicinal plants Mice Mice, Inbred C57BL NF-kappa B - metabolism NF-κB protein NFATC Transcription Factors - metabolism NF‐κB Oophorectomy Original osteoclast Osteoclastogenesis Osteoclasts Osteoclasts - drug effects Osteoclasts - metabolism Osteoclasts - pathology Osteogenesis - drug effects Osteoporosis Osteoprotegerin - metabolism Ovariectomy Phosphatase Phosphatidylinositol 3-Kinases - metabolism Phosphorylation PI3K/AKT Proto-Oncogene Proteins c-akt - metabolism RANK Ligand - pharmacology RANKL RAW 264.7 Cells Reactive Oxygen Species - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Signal transduction Signal Transduction - drug effects TRANCE protein Tumor necrosis factor-TNF
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