Cytisine attenuates bone loss of ovariectomy mouse by preventing RANKL‐induced osteoclastogenesis

Postmenopausal Osteoporosis (PMOP) is oestrogen withdrawal characterized of much production and activation by osteoclast in the elderly female. Cytisine is a quinolizidine alkaloid that comes from seeds or other plants of the Leguminosae (Fabaceae) family. Cytisine has been shown several potential p...

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Veröffentlicht in:	Journal of cellular and molecular medicine 2020-09, Vol.24 (17), p.10112-10127
Hauptverfasser:	Qian, Zhi, Zhong, Zeyuan, Ni, Shuo, Li, Dejian, Zhang, Fangxue, Zhou, Ying, Kang, Zhanrong, Qian, Jun, Yu, Baoqing
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Acid phosphatase (tartrate-resistant) Acids Actin AKT protein AKT‐NFATc1 Alkaloids - metabolism Animals Antibiotics Antibodies Azocines - metabolism Bone growth Bone loss Bone marrow Bone resorption Bone Resorption - metabolism Cathepsin K Cell culture cytisine Cytokines Estrogens Female Kinases Laboratory animals MAP kinase MAPK Mice Mice, Inbred C57BL Mineralization Monocytes NF-kappa B - metabolism NF‐κB Oophorectomy Original Osteoclastogenesis Osteoclasts - metabolism Osteogenesis - physiology Osteoporosis Ovariectomy Ovariectomy - methods Phosphatase Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Post-menopause Proto-Oncogene Proteins c-akt - metabolism Quinolizines - metabolism RANK Ligand - metabolism RAW 264.7 Cells SC79 Seeds Signal transduction Signal Transduction - physiology TRAF6 protein TRANCE protein Tumor necrosis factor-TNF
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