Perinatal androgens organize sex differences in mast cells and attenuate anaphylaxis severity into adulthood

Mast cell (MC)-associated diseases, including allergy/anaphylaxis and neuroinflammatory pain disorders, exhibit a sex bias, with females at increase risk. While much attention has been directed toward adult sex hormones as drivers of sex differences, that female sex bias in MC-associated diseases is...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2020-09, Vol.117 (38), p.23751-23761
Hauptverfasser:	Mackey, Emily, Thelen, Kyan M., Bali, Vedrana, Fardisi, Mahsa, Trowbridge, Madalyn, Jordan, Cynthia L., Moeser, Adam J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adults Allergies Anaphylaxis Androgens Androgens - pharmacology Animal models Animals Bias Biological Sciences Bone marrow Degranulation Disease Models, Animal Female Females Gender aspects Gender differences Health risks Histamine Hormones Inflammation Life span Male Males Mast cells Mast Cells - drug effects Mast Cells - physiology Mice Mice, Transgenic Osteoprogenitor cells Perinatal exposure Phenotypes Puberty Serotonin Sex differences Sex Factors Sex hormones Testis - cytology Testis - drug effects Testosterone
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