CSF1R inhibition by a small-molecule inhibitor is not microglia specific; affecting hematopoiesis and the function of macrophages

Colony-stimulating factor 1 receptor (CSF1R) inhibition has been proposed as a method for microglia depletion, with the assumption that it does not affect peripheral immune cells. Here, we show that CSF1R inhibition by PLX5622 indeed affects the myeloid and lymphoid compartments, causes long-term ch...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2020-09, Vol.117 (38), p.23336-23338
Hauptverfasser:	Lei, Fengyang, Cui, Naiwen, Zhou, Chengxin, Chodosh, James
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Sciences Bone marrow BRIEF REPORT Central nervous system Colony-stimulating factor Depletion Endotoxins Hematopoiesis Immune system Interleukins Long bone Macrophage colony-stimulating factor Macrophages Microglia Monocytes Peritoneum Phagocytosis Spleen
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!