Polar functional group-containing glycolipid CD1d ligands modulate cytokine-biasing responses and prevent experimental colitis

The MHC class I-like molecule CD1d is a nonpolymorphic antigen-presenting glycoprotein, and its ligands include glycolipids, such as α-GalCer. The complexes between CD1d and ligands activate natural killer T cells by T cell receptor recognition, leading to the secretion of various cytokines (IFN-γ,...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Scientific reports 2020-09, Vol.10 (1), p.15766, Article 15766
Hauptverfasser:	Inuki, Shinsuke, Hirata, Natsumi, Kashiwabara, Emi, Kishi, Junichiro, Aiba, Toshihiko, Teratani, Toshiaki, Nakamura, Wataru, Kojima, Yoshimi, Maruyama, Toru, Kanai, Takanori, Fujimoto, Yukari
Format:	Artikel
Sprache:	eng
Schlagworte:	631/92/72 692/308/153 Animals Antigens, CD1d - metabolism Colitis, Ulcerative - metabolism Colitis, Ulcerative - prevention & control Cytokines - metabolism Disease Models, Animal Drug Design Galactosylceramides - chemistry Galactosylceramides - metabolism Galactosylceramides - pharmacology Glycolipids - metabolism Humanities and Social Sciences Ligands Mice multidisciplinary Science Science (multidisciplinary) Solubility Structure-Activity Relationship Water - chemistry
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!