Challenging the Relevance of Unbound Tissue-to-Blood Partition Coefficient (Kpuu) on Prediction of Drug-Drug Interactions

Purpose To examine the theoretical/practical utility of the liver-to-blood partition coefficient ( Kp uu ) for predicting drug-drug interactions (DDIs), and compare the Kp uu -approach to the extended clearance concept AUC R -approach. Methods The Kp uu relationship was derived from first principles...

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