A 5′ UTR GGN repeat controls localisation and translation of a potassium leak channel mRNA through G-quadruplex formation

Abstract RNA G-quadruplexes (G4s) are secondary structures proposed to function as regulators of post-transcriptional mRNA localisation and translation. G4s within some neuronal mRNAs are known to control distal localisation and local translation, contributing to distinct local proteomes that facili...

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Veröffentlicht in:	Nucleic acids research 2020-09, Vol.48 (17), p.9822-9839
Hauptverfasser:	Maltby, Connor J, Schofield, James P R, Houghton, Steven D, O’Kelly, Ita, Vargas-Caballero, Mariana, Deinhardt, Katrin, Coldwell, Mark J
Format:	Artikel
Sprache:	eng
Schlagworte:	5' Untranslated Regions Animals Brain - cytology Brain - metabolism Cells, Cultured G-Quadruplexes HEK293 Cells Humans Membrane Potentials Mice Mice, Inbred C57BL Molecular Biology Neurons - metabolism Neurons - physiology Potassium Channels - chemistry Potassium Channels - genetics Potassium Channels - metabolism Protein Transport RNA, Messenger - chemistry RNA, Messenger - genetics
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