Comprehensive Genomic Analysis of Metastatic Mucinous Urethral Adenocarcinoma Guides Precision Oncology Treatment: Targetable EGFR Amplification Leading to Successful Treatment with Erlotinib

Abstract Male mucinous adenocarcinoma of the urethra (MAU) is a rare tumor for which no standards exist to guide systemic therapy. Here we describe a case of a man with MAU whose tumor was comprehensively analyzed with whole exome, long insert whole genome and transcriptome sequencing. Among many al...

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Veröffentlicht in:	Clinical genitourinary cancer 2017-08, Vol.15 (4), p.e727-e734
Hauptverfasser:	Bryce, Alan H, Borad, Mitesh J, Egan, Jan B, Condjella, Rachel M, Liang, Winnie S, Fonseca, Rafael, McCullough, Ann E, Hunt, Katherine S, Ritacca, Nicole R, Barrett, Michael T, Patel, Maitray D, Young, Scott W, Silva, Alvin C, Ho, Thai H, Halfdanarson, Thorvardur R, Stanton, Melissa L, Cheville, John, Swanson, Scott, Schneider, Daniel E, McWilliams, Robert R, Baker, Angela, Aldrich, Jessica, Kurdoglu, Ahmet, Izatt, Tyler, Christoforides, Alexis, Cherni, Irene, Nasser, Sara, Reiman, Rebecca, Cuyugan, Lori, McDonald, Jacquelyn, Adkins, Jonathan, Mastrian, Stephen D, Von Hoff, Daniel D, Craig, David W, Stewart, A. Keith, Carpten, John D
Format:	Artikel
Sprache:	eng
Schlagworte:	EGFR Exome Genome Hematology, Oncology and Palliative Medicine Transcriptome Urethral adenocarcinoma Urology
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