The phytochemical epigallocatechin gallate prolongs the lifespan by improving lipid metabolism, reducing inflammation and oxidative stress in high‐fat diet‐fed obese rats

We have recently reported that epigallocatechin gallate (EGCG) could extend lifespan in healthy rats. This study aimed to investigate the effects and mechanisms of a high dose of EGCG in extending the lifespan of obese rats. Ninety adult male Wistar rats were randomly divided into the control (NC),...

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Veröffentlicht in:	Aging cell 2020-09, Vol.19 (9), p.e13199-n/a
Hauptverfasser:	Yuan, Hang, Li, Yuqiao, Ling, Fan, Guan, Yue, Zhang, Dandan, Zhu, Qiushuang, Liu, Jinxiao, Wu, Yuqing, Niu, Yucun
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Anti-inflammatory diet Catechin Cholesterol Dextrose EGCG Epigallocatechin gallate Epigallocatechin-3-gallate Fatty acids FOXO1 protein free fatty acid Gene expression Glucose High fat diet high‐fat dietary Hydrogen peroxide Inflammation Life span lifespan Lipid metabolism Lipids Liver Metabolism Obesity Original Oxidative metabolism Oxidative stress Physiological aspects Phytochemicals Protein turnover Proteomes proteomics Rodents SIRT1 protein transcriptome
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