A Fad too Far? Dietary Strategies for the Prevention and Treatment of NAFLD
Nonalcoholic fatty liver disease (NAFLD) is a major health problem, and its prevalence has increased in recent years, concurrent with rising rates of obesity and other metabolic diseases. Currently, there are no FDA‐approved pharmacological therapies for NAFLD, and lifestyle interventions, including...
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| Veröffentlicht in: | Obesity (Silver Spring, Md.) Md.), 2020-10, Vol.28 (10), p.1843-1852 |
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| creator | Moore, Mary P. Cunningham, Rory P. Dashek, Ryan J. Mucinski, Justine M. Rector, R. Scott |
| description | Nonalcoholic fatty liver disease (NAFLD) is a major health problem, and its prevalence has increased in recent years, concurrent with rising rates of obesity and other metabolic diseases. Currently, there are no FDA‐approved pharmacological therapies for NAFLD, and lifestyle interventions, including weight loss and exercise, remain the cornerstones for treatment. Manipulating diet composition and eating patterns may be a sustainable approach to NAFLD treatment. Dietary strategies including Paleolithic, ketogenic, Mediterranean, high‐protein, plant‐based, low‐carbohydrate, and intermittent fasting diets have become increasingly popular because of their purported benefits on metabolic disease. This review highlights what is currently known about these popular dietary approaches in the management of NAFLD in clinical populations with mechanistic insight from animal studies. It also identifies key knowledge gaps to better inform future preclinical and clinical studies aimed at the treatment of NAFLD. |
| doi_str_mv | 10.1002/oby.22964 |
| format | Article |
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Dietary strategies including Paleolithic, ketogenic, Mediterranean, high‐protein, plant‐based, low‐carbohydrate, and intermittent fasting diets have become increasingly popular because of their purported benefits on metabolic disease. This review highlights what is currently known about these popular dietary approaches in the management of NAFLD in clinical populations with mechanistic insight from animal studies. It also identifies key knowledge gaps to better inform future preclinical and clinical studies aimed at the treatment of NAFLD.</description><identifier>ISSN: 1930-7381</identifier><identifier>EISSN: 1930-739X</identifier><identifier>DOI: 10.1002/oby.22964</identifier><identifier>PMID: 32893456</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Biopsy ; Carbohydrates ; Cytokines ; Diabetes ; Diet ; Disease prevention ; Drug therapy ; Exercise ; Fatty acids ; Fitness training programs ; Gastrointestinal surgery ; Humans ; Inflammation ; Insulin resistance ; Lifestyles ; Liver diseases ; Metabolism ; Non-alcoholic Fatty Liver Disease - diet therapy ; Non-alcoholic Fatty Liver Disease - physiopathology ; Non-alcoholic Fatty Liver Disease - prevention & control ; Obesity ; Oxidative stress ; Paleolithic ; Pathophysiology ; Popularity ; Weight control</subject><ispartof>Obesity (Silver Spring, Md.), 2020-10, Vol.28 (10), p.1843-1852</ispartof><rights>2020 The Obesity Society.</rights><rights>Copyright Blackwell Publishing Ltd. 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Scott</creatorcontrib><title>A Fad too Far? Dietary Strategies for the Prevention and Treatment of NAFLD</title><title>Obesity (Silver Spring, Md.)</title><addtitle>Obesity (Silver Spring)</addtitle><description>Nonalcoholic fatty liver disease (NAFLD) is a major health problem, and its prevalence has increased in recent years, concurrent with rising rates of obesity and other metabolic diseases. Currently, there are no FDA‐approved pharmacological therapies for NAFLD, and lifestyle interventions, including weight loss and exercise, remain the cornerstones for treatment. Manipulating diet composition and eating patterns may be a sustainable approach to NAFLD treatment. Dietary strategies including Paleolithic, ketogenic, Mediterranean, high‐protein, plant‐based, low‐carbohydrate, and intermittent fasting diets have become increasingly popular because of their purported benefits on metabolic disease. This review highlights what is currently known about these popular dietary approaches in the management of NAFLD in clinical populations with mechanistic insight from animal studies. 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| source | MEDLINE; Wiley Free Archive; Wiley Online Library Journals Frontfile Complete |
| subjects | Biopsy Carbohydrates Cytokines Diabetes Diet Disease prevention Drug therapy Exercise Fatty acids Fitness training programs Gastrointestinal surgery Humans Inflammation Insulin resistance Lifestyles Liver diseases Metabolism Non-alcoholic Fatty Liver Disease - diet therapy Non-alcoholic Fatty Liver Disease - physiopathology Non-alcoholic Fatty Liver Disease - prevention & control Obesity Oxidative stress Paleolithic Pathophysiology Popularity Weight control |
| title | A Fad too Far? Dietary Strategies for the Prevention and Treatment of NAFLD |
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