Obesity attenuates the effect of sleep apnea on active TGF-ß1 levels and tumor aggressiveness in patients with melanoma

Active transforming growth factor-β1 (TGF-β1), a cytokine partially regulated by hypoxia and obesity, has been related with poor prognosis in several tumors. We determine whether obstructive sleep apnea (OSA) increases serum levels of active TGF-β1 in patients with cutaneous melanoma (CM), assess th...

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Veröffentlicht in:	Scientific reports 2020-09, Vol.10 (1), p.15528-15528, Article 15528
Hauptverfasser:	Cubillos-Zapata, Carolina, Martínez-García, Miguel Ángel, Díaz-García, Elena, Jaureguizar, Ana, Campos-Rodríguez, Francisco, Sánchez-de-la-Torre, Manuel, Nagore, Eduardo, Martorell-Calatayud, Antonio, Blasco, Luis Hernández, Pastor, Esther, Abad-Capa, Jorge, Montserrat, Josep María, Cabriada-Nuño, Valentín, Cano-Pumarega, Irene, Corral-Peñafiel, Jaime, Arias, Eva, Mediano, Olga, Somoza-González, María, Dalmau-Arias, Joan, Almendros, Isaac, Farré, Ramón, López-Collazo, Eduardo, Gozal, David, García-Río, Francisco
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67 692/308 692/4028 692/420 692/699 Adult Aged Cell Line, Tumor Female Humanities and Social Sciences Humans Leptin - blood Male Melanoma - blood Melanoma - complications Melanoma - pathology Melanoma, Cutaneous Malignant Middle Aged multidisciplinary Obesity - blood Obesity - complications Science Science (multidisciplinary) Skin Neoplasms - blood Skin Neoplasms - complications Skin Neoplasms - pathology Sleep Apnea, Obstructive - blood Sleep Apnea, Obstructive - complications Transforming Growth Factor beta1 - blood
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