A Mouse-Adapted SARS-CoV-2 Induces Acute Lung Injury and Mortality in Standard Laboratory Mice

The SARS-CoV-2 pandemic has caused extreme human suffering and economic harm. We generated and characterized a new mouse-adapted SARS-CoV-2 virus that captures multiple aspects of severe COVID-19 disease in standard laboratory mice. This SARS-CoV-2 model exhibits the spectrum of morbidity and mortal...

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Veröffentlicht in:	Cell 2020-11, Vol.183 (4), p.1070-1085.e12
Hauptverfasser:	Leist, Sarah R., Dinnon, Kenneth H., Schäfer, Alexandra, Tse, Longping V., Okuda, Kenichi, Hou, Yixuan J., West, Ande, Edwards, Caitlin E., Sanders, Wes, Fritch, Ethan J., Gully, Kendra L., Scobey, Trevor, Brown, Ariane J., Sheahan, Timothy P., Moorman, Nathaniel J., Boucher, Richard C., Gralinski, Lisa E., Montgomery, Stephanie A., Baric, Ralph S.
Format:	Artikel
Sprache:	eng
Schlagworte:	acute lung injury Acute Lung Injury - pathology acute respiratory distress syndrome animal models Animals Betacoronavirus - isolation & purification Betacoronavirus - pathogenicity Betacoronavirus - physiology Cell Line Chemokines - blood Coronavirus Infections - mortality Coronavirus Infections - pathology Coronavirus Infections - virology COVID-19 Cytokines - blood Disease Models, Animal Female Humans interferon Lung - pathology Lung - physiology Lung - virology Mice Mice, Inbred BALB C Mice, Inbred C57BL mouse-adaptation Pandemics Pneumonia, Viral - mortality Pneumonia, Viral - pathology Pneumonia, Viral - virology Resource Respiratory Distress Syndrome - pathology SARS-CoV-2 Severity of Illness Index Survival Rate vaccines
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