Inhibition of myeloperoxidase increases revascularization and improves blood flow in a diabetic mouse model of hindlimb ischaemia

Objective: Diabetes mellitus is a significant risk factor for peripheral artery disease. Diabetes mellitus induces chronic states of oxidative stress and vascular inflammation that increase neutrophil activation and release of myeloperoxidase. The goal of this study is to determine whether inhibitin...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Diabetes & vascular disease research 2020-03, Vol.17 (3), p.1479164120907971-1479164120907971
Hauptverfasser:	Weihrauch, Dorothee, Martin, Dustin P, Jones, Deron, Krolikowski, John, Struve, Janine, Naylor, Stephen, Pritchard, Kirkwood A
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Inducing Agents - pharmacology Animals Brief Report Cell Movement - drug effects Cell Proliferation - drug effects Cells, Cultured Diabetes Mellitus - genetics Diabetes Mellitus - metabolism Diabetes Mellitus - physiopathology Disease Models, Animal Enzyme Inhibitors - pharmacology Extracellular Matrix - metabolism Hindlimb Human Umbilical Vein Endothelial Cells - drug effects Human Umbilical Vein Endothelial Cells - metabolism Humans Ischemia - drug therapy Ischemia - enzymology Ischemia - physiopathology Male Mice, Inbred C57BL Mice, Knockout Muscle, Skeletal - blood supply Neovascularization, Physiologic - drug effects Neutrophil Infiltration - drug effects Neutrophils - drug effects Neutrophils - enzymology Oligopeptides - pharmacology Oxidative Stress - drug effects Peroxidase - antagonists & inhibitors Peroxidase - metabolism Receptors, Leptin - deficiency Receptors, Leptin - genetics Regional Blood Flow Signal Transduction
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!