In Vitro Susceptibility of Treponema pallidum subsp. pallidum to Doxycycline
Doxycycline is regarded as an effective therapy for early syphilis, and there is increasing interest in using doxycycline for prophylaxis of this infection. However, the MIC of doxycycline for subsp. has not been reported previously. In this study, an culture system was utilized to determine that th...
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| Veröffentlicht in: | Antimicrobial agents and chemotherapy 2020-09, Vol.64 (10) |
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| creator | Edmondson, Diane G Wormser, Gary P Norris, Steven J |
| description | Doxycycline is regarded as an effective therapy for early syphilis, and there is increasing interest in using doxycycline for prophylaxis of this infection. However, the MIC of doxycycline for
subsp.
has not been reported previously. In this study, an
culture system was utilized to determine that the MIC of doxycycline is 0.06 to 0.10 μg/ml for four strains of
subsp.
(Nichols, SS14, UW231B, and UW249B). The Nichols strain cultured
with doxycycline was also tested for infectivity in rabbits, and the minimum bactericidal concentration (MBC) was found to be ≤0.1 μg/ml using this method. The low MIC and MBC values are consistent with the previously demonstrated clinical efficacy of doxycycline for the treatment of early syphilis. This study represents the first report of the
susceptibility of
to doxycycline, and the resulting information may be useful in the consideration of doxycycline for use in prevention of syphilis. |
| doi_str_mv | 10.1128/AAC.00979-20 |
| format | Article |
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subsp.
has not been reported previously. In this study, an
culture system was utilized to determine that the MIC of doxycycline is 0.06 to 0.10 μg/ml for four strains of
subsp.
(Nichols, SS14, UW231B, and UW249B). The Nichols strain cultured
with doxycycline was also tested for infectivity in rabbits, and the minimum bactericidal concentration (MBC) was found to be ≤0.1 μg/ml using this method. The low MIC and MBC values are consistent with the previously demonstrated clinical efficacy of doxycycline for the treatment of early syphilis. This study represents the first report of the
susceptibility of
to doxycycline, and the resulting information may be useful in the consideration of doxycycline for use in prevention of syphilis.</description><identifier>ISSN: 0066-4804</identifier><identifier>ISSN: 1098-6596</identifier><identifier>EISSN: 1098-6596</identifier><identifier>DOI: 10.1128/AAC.00979-20</identifier><identifier>PMID: 32718967</identifier><language>eng</language><publisher>United States: American Society for Microbiology</publisher><subject>Animals ; Doxycycline - pharmacology ; Editor's Pick ; Rabbits ; Susceptibility ; Syphilis - drug therapy ; Treponema ; Treponema pallidum</subject><ispartof>Antimicrobial agents and chemotherapy, 2020-09, Vol.64 (10)</ispartof><rights>Copyright © 2020 American Society for Microbiology.</rights><rights>Copyright © 2020 American Society for Microbiology. 2020 American Society for Microbiology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a418t-33b1b3eca91a8542afdc88f7e13b103c56aeb8028ffd9c0e73ebb23c1cb6c7eb3</citedby><cites>FETCH-LOGICAL-a418t-33b1b3eca91a8542afdc88f7e13b103c56aeb8028ffd9c0e73ebb23c1cb6c7eb3</cites><orcidid>0000-0003-3702-9715 ; 0000-0002-2501-8034</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7508625/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7508625/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32718967$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Edmondson, Diane G</creatorcontrib><creatorcontrib>Wormser, Gary P</creatorcontrib><creatorcontrib>Norris, Steven J</creatorcontrib><title>In Vitro Susceptibility of Treponema pallidum subsp. pallidum to Doxycycline</title><title>Antimicrobial agents and chemotherapy</title><addtitle>Antimicrob Agents Chemother</addtitle><addtitle>Antimicrob Agents Chemother</addtitle><description>Doxycycline is regarded as an effective therapy for early syphilis, and there is increasing interest in using doxycycline for prophylaxis of this infection. However, the MIC of doxycycline for
subsp.
has not been reported previously. In this study, an
culture system was utilized to determine that the MIC of doxycycline is 0.06 to 0.10 μg/ml for four strains of
subsp.
(Nichols, SS14, UW231B, and UW249B). The Nichols strain cultured
with doxycycline was also tested for infectivity in rabbits, and the minimum bactericidal concentration (MBC) was found to be ≤0.1 μg/ml using this method. The low MIC and MBC values are consistent with the previously demonstrated clinical efficacy of doxycycline for the treatment of early syphilis. This study represents the first report of the
susceptibility of
to doxycycline, and the resulting information may be useful in the consideration of doxycycline for use in prevention of syphilis.</description><subject>Animals</subject><subject>Doxycycline - pharmacology</subject><subject>Editor's Pick</subject><subject>Rabbits</subject><subject>Susceptibility</subject><subject>Syphilis - drug therapy</subject><subject>Treponema</subject><subject>Treponema pallidum</subject><issn>0066-4804</issn><issn>1098-6596</issn><issn>1098-6596</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUtLxDAUhYMoOj52rqVLBTveJG2aboRhfA0MuPCxDUkm1QxtU5NW7L-3OuNr4epyOB_ncu9B6BDDGGPCzyaT6Rggz_KYwAYaYch5zNKcbaIRAGNxwiHZQbshLGHQaQ7baIeSDPOcZSM0n9XRo229i-66oE3TWmVL2_aRK6J7bxpXm0pGjSxLu-iqKHQqNOMf3browr31utelrc0-2ipkGczBeu6hh6vL--lNPL-9nk0n81gmmLcxpQorarTMseRpQmSx0JwXmcGDAVSnTBrFgfCiWOQaTEaNUoRqrBXTmVF0D52vcptOVWahTd16WYrG20r6XjhpxV-nts_iyb2KLAXOSDoEHK8DvHvpTGhFZYfry1LWxnVBkIRwYBgSPKCnK1R7F4I3xfcaDOKjADEUID4LEAQG_GSFy1ARsXSdr4dP_Mce_T7jO_irHfoONXWPug</recordid><startdate>20200921</startdate><enddate>20200921</enddate><creator>Edmondson, Diane G</creator><creator>Wormser, Gary P</creator><creator>Norris, Steven J</creator><general>American Society for Microbiology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-3702-9715</orcidid><orcidid>https://orcid.org/0000-0002-2501-8034</orcidid></search><sort><creationdate>20200921</creationdate><title>In Vitro Susceptibility of Treponema pallidum subsp. pallidum to Doxycycline</title><author>Edmondson, Diane G ; Wormser, Gary P ; Norris, Steven J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a418t-33b1b3eca91a8542afdc88f7e13b103c56aeb8028ffd9c0e73ebb23c1cb6c7eb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Animals</topic><topic>Doxycycline - pharmacology</topic><topic>Editor's Pick</topic><topic>Rabbits</topic><topic>Susceptibility</topic><topic>Syphilis - drug therapy</topic><topic>Treponema</topic><topic>Treponema pallidum</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Edmondson, Diane G</creatorcontrib><creatorcontrib>Wormser, Gary P</creatorcontrib><creatorcontrib>Norris, Steven J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Antimicrobial agents and chemotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Edmondson, Diane G</au><au>Wormser, Gary P</au><au>Norris, Steven J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In Vitro Susceptibility of Treponema pallidum subsp. pallidum to Doxycycline</atitle><jtitle>Antimicrobial agents and chemotherapy</jtitle><stitle>Antimicrob Agents Chemother</stitle><addtitle>Antimicrob Agents Chemother</addtitle><date>2020-09-21</date><risdate>2020</risdate><volume>64</volume><issue>10</issue><issn>0066-4804</issn><issn>1098-6596</issn><eissn>1098-6596</eissn><abstract>Doxycycline is regarded as an effective therapy for early syphilis, and there is increasing interest in using doxycycline for prophylaxis of this infection. However, the MIC of doxycycline for
subsp.
has not been reported previously. In this study, an
culture system was utilized to determine that the MIC of doxycycline is 0.06 to 0.10 μg/ml for four strains of
subsp.
(Nichols, SS14, UW231B, and UW249B). The Nichols strain cultured
with doxycycline was also tested for infectivity in rabbits, and the minimum bactericidal concentration (MBC) was found to be ≤0.1 μg/ml using this method. The low MIC and MBC values are consistent with the previously demonstrated clinical efficacy of doxycycline for the treatment of early syphilis. This study represents the first report of the
susceptibility of
to doxycycline, and the resulting information may be useful in the consideration of doxycycline for use in prevention of syphilis.</abstract><cop>United States</cop><pub>American Society for Microbiology</pub><pmid>32718967</pmid><doi>10.1128/AAC.00979-20</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-3702-9715</orcidid><orcidid>https://orcid.org/0000-0002-2501-8034</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Doxycycline - pharmacology Editor's Pick Rabbits Susceptibility Syphilis - drug therapy Treponema Treponema pallidum |
| title | In Vitro Susceptibility of Treponema pallidum subsp. pallidum to Doxycycline |
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