Antiretroviral Penetration and Drug Transporter Concentrations in the Spleens of Three Preclinical Animal Models and Humans

Adequate antiretroviral (ARV) concentrations in lymphoid tissues are critical for optimal antiretroviral therapy (ART). While the spleen contains 25% of the body's lymphocytes, there are minimal data on ARV penetration in this organ. This study quantified total and protein-unbound splenic ARV c...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy 2020-09, Vol.64 (10)
Hauptverfasser:	Devanathan, Aaron S, Fallon, John K, White, Nicole R, Schauer, Amanda P, Van Horne, Brian, Blake, Kimberly, Sykes, Craig, Kovarova, Martina, Adamson, Lourdes, Remling-Mulder, Leila, Luciw, Paul, Garcia, J Victor, Akkina, Ramesh, Pirone, Jason R, Smith, Philip C, Kashuba, Angela D M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-HIV Agents - therapeutic use ATP Binding Cassette Transporter, Subfamily G, Member 2 Chromatography, Liquid HIV Infections - drug therapy Humans Macaca mulatta Mice Models, Animal Neoplasm Proteins Pharmaceutical Preparations Pharmacology Spleen Tandem Mass Spectrometry
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