Neural and Hormonal Control of Sexual Behavior
Abstract Gonadal hormones contribute to the sexual differentiation of brain and behavior throughout the lifespan, from initial neural patterning to “activation” of adult circuits. Sexual behavior is an ideal system in which to investigate the mechanisms underlying hormonal activation of neural circu...
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| Veröffentlicht in: | Endocrinology (Philadelphia) 2020-10, Vol.161 (10), p.1 |
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| creator | Jennings, Kimberly J de Lecea, Luis |
| description | Abstract
Gonadal hormones contribute to the sexual differentiation of brain and behavior throughout the lifespan, from initial neural patterning to “activation” of adult circuits. Sexual behavior is an ideal system in which to investigate the mechanisms underlying hormonal activation of neural circuits. Sexual behavior is a hormonally regulated, innate social behavior found across species. Although both sexes seek out and engage in sexual behavior, the specific actions involved in mating are sexually dimorphic. Thus, the neural circuits mediating sexual motivation and behavior in males and females are overlapping yet distinct. Furthermore, sexual behavior is strongly dependent on circulating gonadal hormones in both sexes. There has been significant recent progress on elucidating how gonadal hormones modulate physiological properties within sexual behavior circuits with consequences for behavior. Therefore, in this mini-review we review the neural circuits of male and female sexual motivation and behavior, from initial sensory detection of pheromones to the extended amygdala and on to medial hypothalamic nuclei and reward systems. We also discuss how gonadal hormones impact the physiology and functioning of each node within these circuits. By better understanding the myriad of ways in which gonadal hormones impact sexual behavior circuits, we can gain a richer and more complete appreciation for the neural substrates of complex behavior. |
| doi_str_mv | 10.1210/endocr/bqaa150 |
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Gonadal hormones contribute to the sexual differentiation of brain and behavior throughout the lifespan, from initial neural patterning to “activation” of adult circuits. Sexual behavior is an ideal system in which to investigate the mechanisms underlying hormonal activation of neural circuits. Sexual behavior is a hormonally regulated, innate social behavior found across species. Although both sexes seek out and engage in sexual behavior, the specific actions involved in mating are sexually dimorphic. Thus, the neural circuits mediating sexual motivation and behavior in males and females are overlapping yet distinct. Furthermore, sexual behavior is strongly dependent on circulating gonadal hormones in both sexes. There has been significant recent progress on elucidating how gonadal hormones modulate physiological properties within sexual behavior circuits with consequences for behavior. Therefore, in this mini-review we review the neural circuits of male and female sexual motivation and behavior, from initial sensory detection of pheromones to the extended amygdala and on to medial hypothalamic nuclei and reward systems. We also discuss how gonadal hormones impact the physiology and functioning of each node within these circuits. By better understanding the myriad of ways in which gonadal hormones impact sexual behavior circuits, we can gain a richer and more complete appreciation for the neural substrates of complex behavior.</description><identifier>ISSN: 0013-7227</identifier><identifier>EISSN: 1945-7170</identifier><identifier>DOI: 10.1210/endocr/bqaa150</identifier><identifier>PMID: 32845294</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Adult ; Amygdala ; Animals ; Brain - physiology ; Circuits ; Endocrinology ; Female ; Hormones ; Hormones - pharmacology ; Hormones - physiology ; Hormones, Sex ; Humans ; Hypothalamus ; Life span ; Male ; Mini-Reviews ; Motivation ; Nerve Net - metabolism ; Nerve Net - physiology ; Neural circuitry ; Neural networks ; Pattern formation ; Pheromones ; Physiological aspects ; Psychological aspects ; Reinforcement ; Sex ; Sex Characteristics ; Sex differences (Psychology) ; Sex differentiation ; Sex Differentiation - drug effects ; Sex Differentiation - physiology ; Sexual behavior ; Sexual Behavior - drug effects ; Sexual Behavior - physiology ; Sexual Behavior - psychology ; Sexual Behavior, Animal - drug effects ; Sexual Behavior, Animal - physiology ; Sexual dimorphism ; Social behavior ; Substrates</subject><ispartof>Endocrinology (Philadelphia), 2020-10, Vol.161 (10), p.1</ispartof><rights>Endocrine Society 2020. 2020</rights><rights>Endocrine Society 2020.</rights><rights>COPYRIGHT 2020 Oxford University Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c585t-8df70f469bbad932420daf39571ad142dd13d8eb8f0a112512498b43fd2c99593</citedby><cites>FETCH-LOGICAL-c585t-8df70f469bbad932420daf39571ad142dd13d8eb8f0a112512498b43fd2c99593</cites><orcidid>0000-0003-0843-5052 ; 0000-0002-8921-5942</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32845294$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jennings, Kimberly J</creatorcontrib><creatorcontrib>de Lecea, Luis</creatorcontrib><title>Neural and Hormonal Control of Sexual Behavior</title><title>Endocrinology (Philadelphia)</title><addtitle>Endocrinology</addtitle><description>Abstract
Gonadal hormones contribute to the sexual differentiation of brain and behavior throughout the lifespan, from initial neural patterning to “activation” of adult circuits. Sexual behavior is an ideal system in which to investigate the mechanisms underlying hormonal activation of neural circuits. Sexual behavior is a hormonally regulated, innate social behavior found across species. Although both sexes seek out and engage in sexual behavior, the specific actions involved in mating are sexually dimorphic. Thus, the neural circuits mediating sexual motivation and behavior in males and females are overlapping yet distinct. Furthermore, sexual behavior is strongly dependent on circulating gonadal hormones in both sexes. There has been significant recent progress on elucidating how gonadal hormones modulate physiological properties within sexual behavior circuits with consequences for behavior. Therefore, in this mini-review we review the neural circuits of male and female sexual motivation and behavior, from initial sensory detection of pheromones to the extended amygdala and on to medial hypothalamic nuclei and reward systems. We also discuss how gonadal hormones impact the physiology and functioning of each node within these circuits. By better understanding the myriad of ways in which gonadal hormones impact sexual behavior circuits, we can gain a richer and more complete appreciation for the neural substrates of complex behavior.</description><subject>Adult</subject><subject>Amygdala</subject><subject>Animals</subject><subject>Brain - physiology</subject><subject>Circuits</subject><subject>Endocrinology</subject><subject>Female</subject><subject>Hormones</subject><subject>Hormones - pharmacology</subject><subject>Hormones - physiology</subject><subject>Hormones, Sex</subject><subject>Humans</subject><subject>Hypothalamus</subject><subject>Life span</subject><subject>Male</subject><subject>Mini-Reviews</subject><subject>Motivation</subject><subject>Nerve Net - metabolism</subject><subject>Nerve Net - physiology</subject><subject>Neural circuitry</subject><subject>Neural networks</subject><subject>Pattern formation</subject><subject>Pheromones</subject><subject>Physiological aspects</subject><subject>Psychological aspects</subject><subject>Reinforcement</subject><subject>Sex</subject><subject>Sex Characteristics</subject><subject>Sex differences (Psychology)</subject><subject>Sex differentiation</subject><subject>Sex Differentiation - drug effects</subject><subject>Sex Differentiation - physiology</subject><subject>Sexual behavior</subject><subject>Sexual Behavior - drug effects</subject><subject>Sexual Behavior - physiology</subject><subject>Sexual Behavior - psychology</subject><subject>Sexual Behavior, Animal - drug effects</subject><subject>Sexual Behavior, Animal - physiology</subject><subject>Sexual dimorphism</subject><subject>Social behavior</subject><subject>Substrates</subject><issn>0013-7227</issn><issn>1945-7170</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>TOX</sourceid><sourceid>EIF</sourceid><recordid>eNqFkU1LAzEQhoMotlavHqXgycO2-dxsLkItagXRg3oO2Xy0W3Y3bbZb9N8baa0KBZnDMJNnXmbyAnCO4ABhBIe2Nl6HYb5UCjF4ALpIUJZwxOEh6EKISMIx5h1w0jTzWFJKyTHoEJxRhgXtgsGTbYMq-6o2_YkPla9jMfb1Kviy713_xb63sXNjZ2pd-HAKjpwqG3u2zT3wdnf7Op4kj8_3D-PRY6JZxlZJZhyHjqYiz5URBFMMjXJEMI6UQRQbg4jJbJ45qBDCDGEqspwSZ7AWggnSA9cb3UWbV9ZoGxdSpVyEolLhQ3pVyL8vdTGTU7-WnEFOIYkCl1uB4JetbVZy7tsQj2skpiwV8S8Y_6GmqrSyqJ2PYroqGi1HKRVQsDRFkRrsoWIYWxXa19YVsb9vQAffNMG63eIIyi_b5MY2ubUtDlz8PneHf_sUgasN4NvFf2KfmsGhZg</recordid><startdate>20201001</startdate><enddate>20201001</enddate><creator>Jennings, Kimberly J</creator><creator>de Lecea, Luis</creator><general>Oxford University Press</general><scope>TOX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-0843-5052</orcidid><orcidid>https://orcid.org/0000-0002-8921-5942</orcidid></search><sort><creationdate>20201001</creationdate><title>Neural and Hormonal Control of Sexual Behavior</title><author>Jennings, Kimberly J ; de Lecea, Luis</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c585t-8df70f469bbad932420daf39571ad142dd13d8eb8f0a112512498b43fd2c99593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Amygdala</topic><topic>Animals</topic><topic>Brain - physiology</topic><topic>Circuits</topic><topic>Endocrinology</topic><topic>Female</topic><topic>Hormones</topic><topic>Hormones - pharmacology</topic><topic>Hormones - physiology</topic><topic>Hormones, Sex</topic><topic>Humans</topic><topic>Hypothalamus</topic><topic>Life span</topic><topic>Male</topic><topic>Mini-Reviews</topic><topic>Motivation</topic><topic>Nerve Net - metabolism</topic><topic>Nerve Net - physiology</topic><topic>Neural circuitry</topic><topic>Neural networks</topic><topic>Pattern formation</topic><topic>Pheromones</topic><topic>Physiological aspects</topic><topic>Psychological aspects</topic><topic>Reinforcement</topic><topic>Sex</topic><topic>Sex Characteristics</topic><topic>Sex differences (Psychology)</topic><topic>Sex differentiation</topic><topic>Sex Differentiation - drug effects</topic><topic>Sex Differentiation - physiology</topic><topic>Sexual behavior</topic><topic>Sexual Behavior - drug effects</topic><topic>Sexual Behavior - physiology</topic><topic>Sexual Behavior - psychology</topic><topic>Sexual Behavior, Animal - drug effects</topic><topic>Sexual Behavior, Animal - physiology</topic><topic>Sexual dimorphism</topic><topic>Social behavior</topic><topic>Substrates</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jennings, Kimberly J</creatorcontrib><creatorcontrib>de Lecea, Luis</creatorcontrib><collection>Oxford Journals Open Access Collection</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Endocrinology (Philadelphia)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jennings, Kimberly J</au><au>de Lecea, Luis</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neural and Hormonal Control of Sexual Behavior</atitle><jtitle>Endocrinology (Philadelphia)</jtitle><addtitle>Endocrinology</addtitle><date>2020-10-01</date><risdate>2020</risdate><volume>161</volume><issue>10</issue><spage>1</spage><pages>1-</pages><issn>0013-7227</issn><eissn>1945-7170</eissn><abstract>Abstract
Gonadal hormones contribute to the sexual differentiation of brain and behavior throughout the lifespan, from initial neural patterning to “activation” of adult circuits. Sexual behavior is an ideal system in which to investigate the mechanisms underlying hormonal activation of neural circuits. Sexual behavior is a hormonally regulated, innate social behavior found across species. Although both sexes seek out and engage in sexual behavior, the specific actions involved in mating are sexually dimorphic. Thus, the neural circuits mediating sexual motivation and behavior in males and females are overlapping yet distinct. Furthermore, sexual behavior is strongly dependent on circulating gonadal hormones in both sexes. There has been significant recent progress on elucidating how gonadal hormones modulate physiological properties within sexual behavior circuits with consequences for behavior. Therefore, in this mini-review we review the neural circuits of male and female sexual motivation and behavior, from initial sensory detection of pheromones to the extended amygdala and on to medial hypothalamic nuclei and reward systems. We also discuss how gonadal hormones impact the physiology and functioning of each node within these circuits. By better understanding the myriad of ways in which gonadal hormones impact sexual behavior circuits, we can gain a richer and more complete appreciation for the neural substrates of complex behavior.</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>32845294</pmid><doi>10.1210/endocr/bqaa150</doi><orcidid>https://orcid.org/0000-0003-0843-5052</orcidid><orcidid>https://orcid.org/0000-0002-8921-5942</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Amygdala Animals Brain - physiology Circuits Endocrinology Female Hormones Hormones - pharmacology Hormones - physiology Hormones, Sex Humans Hypothalamus Life span Male Mini-Reviews Motivation Nerve Net - metabolism Nerve Net - physiology Neural circuitry Neural networks Pattern formation Pheromones Physiological aspects Psychological aspects Reinforcement Sex Sex Characteristics Sex differences (Psychology) Sex differentiation Sex Differentiation - drug effects Sex Differentiation - physiology Sexual behavior Sexual Behavior - drug effects Sexual Behavior - physiology Sexual Behavior - psychology Sexual Behavior, Animal - drug effects Sexual Behavior, Animal - physiology Sexual dimorphism Social behavior Substrates |
| title | Neural and Hormonal Control of Sexual Behavior |
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