Correlation Between Low-Dose Chest Computed Tomography and RT-PCR Results for the Diagnosis of COVID-19: A Report of 27,824 Cases in Tehran, Iran
Real-time polymerase chain reaction (RT-PCR) remains the gold standard for confirmation of Coronavirus Disease 2019 (COVID-19) despite having many disadvantages. Here, we investigated the diagnostic performance of chest computed tomography (CT) as an alternative to RT-PCR in patients with clinical s...
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| Veröffentlicht in: | Academic radiology 2021-12, Vol.28 (12), p.1654-1661 |
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| creator | Zali, Alireza Sohrabi, Mohammad-Reza Mahdavi, Ali Khalili, Nastaran Taheri, Morteza Sanei Maher, Ali Sadoughi, Mohammadmehdi Zarghi, Afshin Ziai, Seyed Ali Shabestari, Abbas Arjmand Bakhshayeshkaram, Mehrdad Haghighatkhah, Hamidreza Salevatipour, Babak Abrishami, Alireza Raoufi, Masoomeh Dehghan, Pooneh Bagheri, Arash Khameneh Khoshnoud, Reza Jalili Hanani, Khatereh |
| description | Real-time polymerase chain reaction (RT-PCR) remains the gold standard for confirmation of Coronavirus Disease 2019 (COVID-19) despite having many disadvantages. Here, we investigated the diagnostic performance of chest computed tomography (CT) as an alternative to RT-PCR in patients with clinical suspicion of COVID-19 infection.
In this descriptive cross-sectional study, 27,824 patients with clinical suspicion of COVID-19 infection who underwent unenhanced low-dose chest CT from 20 February, 2020 to 21 May, 2020 were evaluated. Patients were recruited from seven specifically designated hospitals for patients with COVID-19 infection affiliated to Shahid Beheshti University of Medical Sciences. In each hospital, images were interpreted by two independent radiologists. CT findings were considered as positive/negative for COVID-19 infection based on RSNA diagnostic criteria. Then, the correlation between the number of daily positive chest CT scans and number of daily PCR-confirmed cases and COVID-19-related deaths in Tehran province during this three-month period was assessed. The trends of admission rate and patients with positive CT scans were also evaluated.
A strong positive correlation between the numbers of daily positive CT scans and daily PCR-confirmed COVID-19 cases (r = 0.913, p < 0.001) was observed. Furthermore, in hospitals located in regions with a lower socioeconomic status, the admission rate and number of positive cases within this three-month period was higher as compared to other hospitals.
Low-dose chest CT is a safe, rapid and reliable alternative to RT-PCR for the diagnosis of COVID-19 in high-prevalence regions. In addition, our study provides further evidence for considering patients’ socioeconomic status as an important risk factor for COVID-19. |
| doi_str_mv | 10.1016/j.acra.2020.09.003 |
| format | Article |
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In this descriptive cross-sectional study, 27,824 patients with clinical suspicion of COVID-19 infection who underwent unenhanced low-dose chest CT from 20 February, 2020 to 21 May, 2020 were evaluated. Patients were recruited from seven specifically designated hospitals for patients with COVID-19 infection affiliated to Shahid Beheshti University of Medical Sciences. In each hospital, images were interpreted by two independent radiologists. CT findings were considered as positive/negative for COVID-19 infection based on RSNA diagnostic criteria. Then, the correlation between the number of daily positive chest CT scans and number of daily PCR-confirmed cases and COVID-19-related deaths in Tehran province during this three-month period was assessed. The trends of admission rate and patients with positive CT scans were also evaluated.
A strong positive correlation between the numbers of daily positive CT scans and daily PCR-confirmed COVID-19 cases (r = 0.913, p < 0.001) was observed. Furthermore, in hospitals located in regions with a lower socioeconomic status, the admission rate and number of positive cases within this three-month period was higher as compared to other hospitals.
Low-dose chest CT is a safe, rapid and reliable alternative to RT-PCR for the diagnosis of COVID-19 in high-prevalence regions. In addition, our study provides further evidence for considering patients’ socioeconomic status as an important risk factor for COVID-19.</description><identifier>ISSN: 1076-6332</identifier><identifier>EISSN: 1878-4046</identifier><identifier>DOI: 10.1016/j.acra.2020.09.003</identifier><identifier>PMID: 33020043</identifier><language>eng</language><publisher>NEW YORK: Elsevier Inc</publisher><subject>computed tomography ; correlation ; COVID-19 ; Cross-Sectional Studies ; diagnosis ; Humans ; Iran - epidemiology ; Life Sciences & Biomedicine ; Original Investigation ; polymerase chain reaction ; Radiology, Nuclear Medicine & Medical Imaging ; Reverse Transcriptase Polymerase Chain Reaction ; RT-PCR ; SARS-CoV-2 ; Science & Technology ; Sensitivity and Specificity ; socioeconomic ; Tomography, X-Ray Computed</subject><ispartof>Academic radiology, 2021-12, Vol.28 (12), p.1654-1661</ispartof><rights>2020 The Association of University Radiologists</rights><rights>Copyright © 2020 The Association of University Radiologists. Published by Elsevier Inc. All rights reserved.</rights><rights>2020 The Association of University Radiologists. Published by Elsevier Inc. All rights reserved. 2020 The Association of University Radiologists</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>12</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000720055900002</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c455t-24fe2151f9cc11345faec9c1568476e19c8715a37bc63bf7537f5a8521e2de123</citedby><cites>FETCH-LOGICAL-c455t-24fe2151f9cc11345faec9c1568476e19c8715a37bc63bf7537f5a8521e2de123</cites><orcidid>0000-0001-8078-3591 ; 0000-0002-1330-6207 ; 0000-0001-5077-4627 ; 0000-0002-0448-284X ; 0000-0003-3666-0476 ; 0000-0002-2298-2290 ; 0000-0002-6811-3955</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.acra.2020.09.003$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,315,781,785,886,3551,27929,27930,39263,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33020043$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zali, Alireza</creatorcontrib><creatorcontrib>Sohrabi, Mohammad-Reza</creatorcontrib><creatorcontrib>Mahdavi, Ali</creatorcontrib><creatorcontrib>Khalili, Nastaran</creatorcontrib><creatorcontrib>Taheri, Morteza Sanei</creatorcontrib><creatorcontrib>Maher, Ali</creatorcontrib><creatorcontrib>Sadoughi, Mohammadmehdi</creatorcontrib><creatorcontrib>Zarghi, Afshin</creatorcontrib><creatorcontrib>Ziai, Seyed Ali</creatorcontrib><creatorcontrib>Shabestari, Abbas Arjmand</creatorcontrib><creatorcontrib>Bakhshayeshkaram, Mehrdad</creatorcontrib><creatorcontrib>Haghighatkhah, Hamidreza</creatorcontrib><creatorcontrib>Salevatipour, Babak</creatorcontrib><creatorcontrib>Abrishami, Alireza</creatorcontrib><creatorcontrib>Raoufi, Masoomeh</creatorcontrib><creatorcontrib>Dehghan, Pooneh</creatorcontrib><creatorcontrib>Bagheri, Arash Khameneh</creatorcontrib><creatorcontrib>Khoshnoud, Reza Jalili</creatorcontrib><creatorcontrib>Hanani, Khatereh</creatorcontrib><title>Correlation Between Low-Dose Chest Computed Tomography and RT-PCR Results for the Diagnosis of COVID-19: A Report of 27,824 Cases in Tehran, Iran</title><title>Academic radiology</title><addtitle>ACAD RADIOL</addtitle><addtitle>Acad Radiol</addtitle><description>Real-time polymerase chain reaction (RT-PCR) remains the gold standard for confirmation of Coronavirus Disease 2019 (COVID-19) despite having many disadvantages. Here, we investigated the diagnostic performance of chest computed tomography (CT) as an alternative to RT-PCR in patients with clinical suspicion of COVID-19 infection.
In this descriptive cross-sectional study, 27,824 patients with clinical suspicion of COVID-19 infection who underwent unenhanced low-dose chest CT from 20 February, 2020 to 21 May, 2020 were evaluated. Patients were recruited from seven specifically designated hospitals for patients with COVID-19 infection affiliated to Shahid Beheshti University of Medical Sciences. In each hospital, images were interpreted by two independent radiologists. CT findings were considered as positive/negative for COVID-19 infection based on RSNA diagnostic criteria. Then, the correlation between the number of daily positive chest CT scans and number of daily PCR-confirmed cases and COVID-19-related deaths in Tehran province during this three-month period was assessed. The trends of admission rate and patients with positive CT scans were also evaluated.
A strong positive correlation between the numbers of daily positive CT scans and daily PCR-confirmed COVID-19 cases (r = 0.913, p < 0.001) was observed. Furthermore, in hospitals located in regions with a lower socioeconomic status, the admission rate and number of positive cases within this three-month period was higher as compared to other hospitals.
Low-dose chest CT is a safe, rapid and reliable alternative to RT-PCR for the diagnosis of COVID-19 in high-prevalence regions. In addition, our study provides further evidence for considering patients’ socioeconomic status as an important risk factor for COVID-19.</description><subject>computed tomography</subject><subject>correlation</subject><subject>COVID-19</subject><subject>Cross-Sectional Studies</subject><subject>diagnosis</subject><subject>Humans</subject><subject>Iran - epidemiology</subject><subject>Life Sciences & Biomedicine</subject><subject>Original Investigation</subject><subject>polymerase chain reaction</subject><subject>Radiology, Nuclear Medicine & Medical Imaging</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>RT-PCR</subject><subject>SARS-CoV-2</subject><subject>Science & Technology</subject><subject>Sensitivity and Specificity</subject><subject>socioeconomic</subject><subject>Tomography, X-Ray Computed</subject><issn>1076-6332</issn><issn>1878-4046</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>HGBXW</sourceid><sourceid>EIF</sourceid><recordid>eNqNks2O0zAUhSMEYoaBF2CBvERiUvwTxwlCSEPKT6VKg6rC1nKdm9ZVahfbmWoegzfGoaWCDWJjX9nfOfb1cZY9J3hCMClfbydKezWhmOIJricYswfZJalElRe4KB-mGosyLxmjF9mTELYYE15W7HF2wVjS4IJdZj8a5z30Khpn0XuIBwCL5u6QT10A1GwgRNS43X6I0KKl27m1V_vNPVK2RYtl_qVZoAWEoY8Bdc6juAE0NWptXTABuQ41t99m05zUb9BNAvfOx3GViuuKFqhRAQIyFi1h45W9RrM0Ps0edaoP8Ow0X2VfP35YNp_z-e2nWXMzz3XBecxp0QElnHS11oSwgncKdK3HDgtRAql1JQhXTKx0yVad4Ex0XFWcEqAtEMqusndH3_2w2kGrwUavern3Zqf8vXTKyL93rNnItbuTgmPOK5YMXp4MvPs-pIeSOxM09L2y4IYgaVFUVUFLgRNKj6j2LgQP3fkYguWYpdzKMUs5ZilxLVOWSfTizwueJb_DS8CrI3CAleuCNmA1nDGMsUgc53Wq8Nhv9f90Y-KvL9G4wcYkfXuUQsrjzoCXJ3lrPOgoW2f-1chPbNjPFQ</recordid><startdate>20211201</startdate><enddate>20211201</enddate><creator>Zali, Alireza</creator><creator>Sohrabi, Mohammad-Reza</creator><creator>Mahdavi, Ali</creator><creator>Khalili, Nastaran</creator><creator>Taheri, Morteza Sanei</creator><creator>Maher, Ali</creator><creator>Sadoughi, Mohammadmehdi</creator><creator>Zarghi, Afshin</creator><creator>Ziai, Seyed Ali</creator><creator>Shabestari, Abbas Arjmand</creator><creator>Bakhshayeshkaram, Mehrdad</creator><creator>Haghighatkhah, Hamidreza</creator><creator>Salevatipour, Babak</creator><creator>Abrishami, Alireza</creator><creator>Raoufi, Masoomeh</creator><creator>Dehghan, Pooneh</creator><creator>Bagheri, Arash Khameneh</creator><creator>Khoshnoud, Reza Jalili</creator><creator>Hanani, Khatereh</creator><general>Elsevier Inc</general><general>Elsevier</general><general>The Association of University Radiologists. 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Here, we investigated the diagnostic performance of chest computed tomography (CT) as an alternative to RT-PCR in patients with clinical suspicion of COVID-19 infection.
In this descriptive cross-sectional study, 27,824 patients with clinical suspicion of COVID-19 infection who underwent unenhanced low-dose chest CT from 20 February, 2020 to 21 May, 2020 were evaluated. Patients were recruited from seven specifically designated hospitals for patients with COVID-19 infection affiliated to Shahid Beheshti University of Medical Sciences. In each hospital, images were interpreted by two independent radiologists. CT findings were considered as positive/negative for COVID-19 infection based on RSNA diagnostic criteria. Then, the correlation between the number of daily positive chest CT scans and number of daily PCR-confirmed cases and COVID-19-related deaths in Tehran province during this three-month period was assessed. The trends of admission rate and patients with positive CT scans were also evaluated.
A strong positive correlation between the numbers of daily positive CT scans and daily PCR-confirmed COVID-19 cases (r = 0.913, p < 0.001) was observed. Furthermore, in hospitals located in regions with a lower socioeconomic status, the admission rate and number of positive cases within this three-month period was higher as compared to other hospitals.
Low-dose chest CT is a safe, rapid and reliable alternative to RT-PCR for the diagnosis of COVID-19 in high-prevalence regions. In addition, our study provides further evidence for considering patients’ socioeconomic status as an important risk factor for COVID-19.</abstract><cop>NEW YORK</cop><pub>Elsevier Inc</pub><pmid>33020043</pmid><doi>10.1016/j.acra.2020.09.003</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-8078-3591</orcidid><orcidid>https://orcid.org/0000-0002-1330-6207</orcidid><orcidid>https://orcid.org/0000-0001-5077-4627</orcidid><orcidid>https://orcid.org/0000-0002-0448-284X</orcidid><orcidid>https://orcid.org/0000-0003-3666-0476</orcidid><orcidid>https://orcid.org/0000-0002-2298-2290</orcidid><orcidid>https://orcid.org/0000-0002-6811-3955</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Academic radiology, 2021-12, Vol.28 (12), p.1654-1661 |
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| source | MEDLINE; Web of Science - Science Citation Index Expanded - 2021<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" />; Access via ScienceDirect (Elsevier) |
| subjects | computed tomography correlation COVID-19 Cross-Sectional Studies diagnosis Humans Iran - epidemiology Life Sciences & Biomedicine Original Investigation polymerase chain reaction Radiology, Nuclear Medicine & Medical Imaging Reverse Transcriptase Polymerase Chain Reaction RT-PCR SARS-CoV-2 Science & Technology Sensitivity and Specificity socioeconomic Tomography, X-Ray Computed |
| title | Correlation Between Low-Dose Chest Computed Tomography and RT-PCR Results for the Diagnosis of COVID-19: A Report of 27,824 Cases in Tehran, Iran |
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