Comparative effectiveness of different consolidation chemotherapy regimens for pediatric acute lymphoblastic leukemia: A protocol for systematic review and network meta analysis
Acute lymphoblastic leukemia (ALL) is one of the most commonly seen cancers in children, which mainly relates with inherited genetic variations. Consolidation chemotherapy is usually given to the pediatric ALL patients, however there is no meta-analysis and network analysis conducting the efficacy o...
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| Veröffentlicht in: | Medicine (Baltimore) 2020-09, Vol.99 (38), p.e22208-e22208 |
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| creator | Chen, Guoming Huang, Ruilan Huang, Zhuoxin Chen, Ziyin Liu, Huiping Wu, Jinfeng Chen, Zhiqiang Gao, Tianqi Xu, Hua Lan, Hai |
| description | Acute lymphoblastic leukemia (ALL) is one of the most commonly seen cancers in children, which mainly relates with inherited genetic variations. Consolidation chemotherapy is usually given to the pediatric ALL patients, however there is no meta-analysis and network analysis conducting the efficacy of the chemotherapy. Therefore, we perform a protocol to assess the efficacy of chemotherapeutics for pediatric ALL.
A literature search for randomized controlled trials about some specific chemotherapy regimens for pediatric ALL will be carried out in 7 electronic databases from their establishment to June 2019: the Cochrane Library, Embase, MEDLINE, the Chinese National Knowledge Infrastructure (CNKI), the Sino Med, the Chinese Scientific Journal Database (VIP) and the Wanfang Database. Complete continuous remission will be measured as primary outcome. Stata 14.0 will be utilized to perform a standard pairwise meta-analysis and the NMA, as well as draw Network Plots of Network Meta.
This network meta-analysis will evaluate the efficacy of different consolidation chemotherapy regimens.
This study will furnish decision-making reference on optimum proposal of chemotherapy regimens for pediatric ALL.
PROSPERO CRD42019134518. |
| doi_str_mv | 10.1097/MD.0000000000022208 |
| format | Article |
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A literature search for randomized controlled trials about some specific chemotherapy regimens for pediatric ALL will be carried out in 7 electronic databases from their establishment to June 2019: the Cochrane Library, Embase, MEDLINE, the Chinese National Knowledge Infrastructure (CNKI), the Sino Med, the Chinese Scientific Journal Database (VIP) and the Wanfang Database. Complete continuous remission will be measured as primary outcome. Stata 14.0 will be utilized to perform a standard pairwise meta-analysis and the NMA, as well as draw Network Plots of Network Meta.
This network meta-analysis will evaluate the efficacy of different consolidation chemotherapy regimens.
This study will furnish decision-making reference on optimum proposal of chemotherapy regimens for pediatric ALL.
PROSPERO CRD42019134518.</description><identifier>ISSN: 0025-7974</identifier><identifier>EISSN: 1536-5964</identifier><identifier>DOI: 10.1097/MD.0000000000022208</identifier><identifier>PMID: 32957354</identifier><language>eng</language><publisher>United States: Lippincott Williams & Wilkins</publisher><subject>Antineoplastic Agents - administration & dosage ; Consolidation Chemotherapy ; Humans ; Meta-Analysis as Topic ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy ; Study Protocol Systematic Review ; Systematic Reviews as Topic</subject><ispartof>Medicine (Baltimore), 2020-09, Vol.99 (38), p.e22208-e22208</ispartof><rights>Lippincott Williams & Wilkins</rights><rights>Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3551-513ece9fa3d79beb617615aaf794d9d4c483cb2d5b98f43f514e88f8018c6be43</cites><orcidid>0000-0002-3739-8935</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7505343/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7505343/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32957354$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Guoming</creatorcontrib><creatorcontrib>Huang, Ruilan</creatorcontrib><creatorcontrib>Huang, Zhuoxin</creatorcontrib><creatorcontrib>Chen, Ziyin</creatorcontrib><creatorcontrib>Liu, Huiping</creatorcontrib><creatorcontrib>Wu, Jinfeng</creatorcontrib><creatorcontrib>Chen, Zhiqiang</creatorcontrib><creatorcontrib>Gao, Tianqi</creatorcontrib><creatorcontrib>Xu, Hua</creatorcontrib><creatorcontrib>Lan, Hai</creatorcontrib><title>Comparative effectiveness of different consolidation chemotherapy regimens for pediatric acute lymphoblastic leukemia: A protocol for systematic review and network meta analysis</title><title>Medicine (Baltimore)</title><addtitle>Medicine (Baltimore)</addtitle><description>Acute lymphoblastic leukemia (ALL) is one of the most commonly seen cancers in children, which mainly relates with inherited genetic variations. Consolidation chemotherapy is usually given to the pediatric ALL patients, however there is no meta-analysis and network analysis conducting the efficacy of the chemotherapy. Therefore, we perform a protocol to assess the efficacy of chemotherapeutics for pediatric ALL.
A literature search for randomized controlled trials about some specific chemotherapy regimens for pediatric ALL will be carried out in 7 electronic databases from their establishment to June 2019: the Cochrane Library, Embase, MEDLINE, the Chinese National Knowledge Infrastructure (CNKI), the Sino Med, the Chinese Scientific Journal Database (VIP) and the Wanfang Database. Complete continuous remission will be measured as primary outcome. Stata 14.0 will be utilized to perform a standard pairwise meta-analysis and the NMA, as well as draw Network Plots of Network Meta.
This network meta-analysis will evaluate the efficacy of different consolidation chemotherapy regimens.
This study will furnish decision-making reference on optimum proposal of chemotherapy regimens for pediatric ALL.
PROSPERO CRD42019134518.</description><subject>Antineoplastic Agents - administration & dosage</subject><subject>Consolidation Chemotherapy</subject><subject>Humans</subject><subject>Meta-Analysis as Topic</subject><subject>Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy</subject><subject>Study Protocol Systematic Review</subject><subject>Systematic Reviews as Topic</subject><issn>0025-7974</issn><issn>1536-5964</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkV2P1CAYhRujccfVX2BiuPSmKxQYihcmm1m_kt14o9eE0pctDi0V6Ez6s_yHtjvr-sEN5OGc8xJOUbwk-IJgKd7cXF3gP6uqKlw_KjaE023J5ZY9LjYL5aWQgp0Vz1L6jjGhomJPizNaSS4oZ5vi5y70o446uwMgsBbMehogJRQsat1CIgwZmTCk4F27CMOATAd9yB1EPc4owq3rYUjIhohGaJ3O0RmkzZQB-bkfu9B4nfLCPEx76J1-iy7RGEMOJvg7W5pThl6vmggHB0ekhxYNkI8h7lEPWS9A-zm59Lx4YrVP8OJ-Py--fXj_dfepvP7y8fPu8ro0lHNSckLBgLSatkI20GyJ2BKutRWStbJlhtXUNFXLG1lbRi0nDOra1pjUZtsAo-fFu1PuODU9tGb5hai9GqPrdZxV0E79ezO4Tt2GgxIcc8roEvD6PiCGHxOkrHqXDHivBwhTUhVjrBa05ussepKaGFKKYB_GEKzWstXNlfq_7MX16u8XPnh-t7sI2ElwDD5DTHs_HSGqDrTP3V0eF7IqK1xhLEmNy5UQ-gvyYrvf</recordid><startdate>20200918</startdate><enddate>20200918</enddate><creator>Chen, Guoming</creator><creator>Huang, Ruilan</creator><creator>Huang, Zhuoxin</creator><creator>Chen, Ziyin</creator><creator>Liu, Huiping</creator><creator>Wu, Jinfeng</creator><creator>Chen, Zhiqiang</creator><creator>Gao, Tianqi</creator><creator>Xu, Hua</creator><creator>Lan, Hai</creator><general>Lippincott Williams & Wilkins</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-3739-8935</orcidid></search><sort><creationdate>20200918</creationdate><title>Comparative effectiveness of different consolidation chemotherapy regimens for pediatric acute lymphoblastic leukemia: A protocol for systematic review and network meta analysis</title><author>Chen, Guoming ; Huang, Ruilan ; Huang, Zhuoxin ; Chen, Ziyin ; Liu, Huiping ; Wu, Jinfeng ; Chen, Zhiqiang ; Gao, Tianqi ; Xu, Hua ; Lan, Hai</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3551-513ece9fa3d79beb617615aaf794d9d4c483cb2d5b98f43f514e88f8018c6be43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Antineoplastic Agents - administration & dosage</topic><topic>Consolidation Chemotherapy</topic><topic>Humans</topic><topic>Meta-Analysis as Topic</topic><topic>Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy</topic><topic>Study Protocol Systematic Review</topic><topic>Systematic Reviews as Topic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Guoming</creatorcontrib><creatorcontrib>Huang, Ruilan</creatorcontrib><creatorcontrib>Huang, Zhuoxin</creatorcontrib><creatorcontrib>Chen, Ziyin</creatorcontrib><creatorcontrib>Liu, Huiping</creatorcontrib><creatorcontrib>Wu, Jinfeng</creatorcontrib><creatorcontrib>Chen, Zhiqiang</creatorcontrib><creatorcontrib>Gao, Tianqi</creatorcontrib><creatorcontrib>Xu, Hua</creatorcontrib><creatorcontrib>Lan, Hai</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medicine (Baltimore)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Guoming</au><au>Huang, Ruilan</au><au>Huang, Zhuoxin</au><au>Chen, Ziyin</au><au>Liu, Huiping</au><au>Wu, Jinfeng</au><au>Chen, Zhiqiang</au><au>Gao, Tianqi</au><au>Xu, Hua</au><au>Lan, Hai</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparative effectiveness of different consolidation chemotherapy regimens for pediatric acute lymphoblastic leukemia: A protocol for systematic review and network meta analysis</atitle><jtitle>Medicine (Baltimore)</jtitle><addtitle>Medicine (Baltimore)</addtitle><date>2020-09-18</date><risdate>2020</risdate><volume>99</volume><issue>38</issue><spage>e22208</spage><epage>e22208</epage><pages>e22208-e22208</pages><issn>0025-7974</issn><eissn>1536-5964</eissn><abstract>Acute lymphoblastic leukemia (ALL) is one of the most commonly seen cancers in children, which mainly relates with inherited genetic variations. Consolidation chemotherapy is usually given to the pediatric ALL patients, however there is no meta-analysis and network analysis conducting the efficacy of the chemotherapy. Therefore, we perform a protocol to assess the efficacy of chemotherapeutics for pediatric ALL.
A literature search for randomized controlled trials about some specific chemotherapy regimens for pediatric ALL will be carried out in 7 electronic databases from their establishment to June 2019: the Cochrane Library, Embase, MEDLINE, the Chinese National Knowledge Infrastructure (CNKI), the Sino Med, the Chinese Scientific Journal Database (VIP) and the Wanfang Database. Complete continuous remission will be measured as primary outcome. Stata 14.0 will be utilized to perform a standard pairwise meta-analysis and the NMA, as well as draw Network Plots of Network Meta.
This network meta-analysis will evaluate the efficacy of different consolidation chemotherapy regimens.
This study will furnish decision-making reference on optimum proposal of chemotherapy regimens for pediatric ALL.
PROSPERO CRD42019134518.</abstract><cop>United States</cop><pub>Lippincott Williams & Wilkins</pub><pmid>32957354</pmid><doi>10.1097/MD.0000000000022208</doi><orcidid>https://orcid.org/0000-0002-3739-8935</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; IngentaConnect Open Access; PubMed Central; Alma/SFX Local Collection; EZB Electronic Journals Library; Wolters Kluwer Open Access |
| subjects | Antineoplastic Agents - administration & dosage Consolidation Chemotherapy Humans Meta-Analysis as Topic Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Study Protocol Systematic Review Systematic Reviews as Topic |
| title | Comparative effectiveness of different consolidation chemotherapy regimens for pediatric acute lymphoblastic leukemia: A protocol for systematic review and network meta analysis |
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