The Role of Nutrition and Inflammation on Cognition in a High-Risk Group for Alzheimer’s Disease

Background: Alzheimer’s disease (AD) is a prevalent neurodegenerative disease. Treatments are necessary to target people at high risk for AD. Inflammation, particularly tumor necrosis factor alpha (TNFα), appears to be an important marker associated with the development of AD pathophysiology. Consum...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:JAD reports 2020-08, Vol.4 (1), p.345-352
Hauptverfasser: Jackson, Jordan M., Bay, Allison A., Barter, Jolie Denise, Ni, Liang, Caudle, William Michael, Serra, Monica C., Wharton, Whitney, Hackney, Madeleine E.
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 352
container_issue 1
container_start_page 345
container_title JAD reports
container_volume 4
creator Jackson, Jordan M.
Bay, Allison A.
Barter, Jolie Denise
Ni, Liang
Caudle, William Michael
Serra, Monica C.
Wharton, Whitney
Hackney, Madeleine E.
description Background: Alzheimer’s disease (AD) is a prevalent neurodegenerative disease. Treatments are necessary to target people at high risk for AD. Inflammation, particularly tumor necrosis factor alpha (TNFα), appears to be an important marker associated with the development of AD pathophysiology. Consuming a high-fat diet induces tissue expression of TNFα. Objective: This study investigates the relationship between nutrition, circulating inflammation, and cognition in African American women (age: M = 59.5 (±8.20) [42–73] years) at risk for developing AD. Methods: Participants were split into high-fat and low-fat groups based on total dietary fat consumption self-reported on the Lower Mississippi Delta Nutrition Intervention Research Initiative Food Frequency Questionnaire (Delta NIRI FFQ). Results: A high-fat diet was associated with increased blood serum TNFα (p = 0.02) compared to the low-fat diet. In addition, global cognition scores were 9.0% better in those who consumed a higher fat diet (p = 0.04). No significant differences across groups were noted for executive function, dual-tasking, and visuospatial performance. Conclusion: These results indicate that there may be multiple biological pathways involved in AD development, suggesting the need for more holistic approaches to mitigate AD-development risk.
doi_str_mv 10.3233/ADR-200224
format Article
fullrecord <record><control><sourceid>sage_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7504978</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.3233_ADR-200224</sage_id><sourcerecordid>10.3233_ADR-200224</sourcerecordid><originalsourceid>FETCH-LOGICAL-c410t-7ffb1aabb34308610a819cb69e4c24d11b3ce1ec03acc5194f6593ea89676fe23</originalsourceid><addsrcrecordid>eNptkNtKAzEQhoMoVmpvfADJnSCs5rSnG6G02haKQqnXIZsm29TdTUl2Bb3yNXw9n8TV1VJBGJhh5pt_mB-AM4yuKKH0ejheBAQhQtgBOCEhIwFLCD3cq3tg4P0GIYQTEkWEHoMepYiwlOETkC3XCi5soaDV8L6pnamNraCoVnBW6UKUpfhutDGyedVNTQvAqcnXwcL4JzhxttlCbR0cFq9rZUrlPt7ePRwbr4RXp-BIi8KrwU_ug8e72-VoGswfJrPRcB5IhlEdxFpnWIgso4yiJMJIJDiVWZQqJglbYZxRqbCSiAopQ5wyHYUpVSJJozjSitA-uOl0t01WqpVUVe1EwbfOlMK9cCsM_zupzJrn9pnHIWJpnLQCl52AdNZ7p_RuFyP-ZTZvzead2S18vn9th_5a2wIXHeBFrvjGNq5qv_9P6hOItIfh</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>The Role of Nutrition and Inflammation on Cognition in a High-Risk Group for Alzheimer’s Disease</title><source>DOAJ Directory of Open Access Journals</source><source>PubMed Central Open Access</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Jackson, Jordan M. ; Bay, Allison A. ; Barter, Jolie Denise ; Ni, Liang ; Caudle, William Michael ; Serra, Monica C. ; Wharton, Whitney ; Hackney, Madeleine E.</creator><creatorcontrib>Jackson, Jordan M. ; Bay, Allison A. ; Barter, Jolie Denise ; Ni, Liang ; Caudle, William Michael ; Serra, Monica C. ; Wharton, Whitney ; Hackney, Madeleine E.</creatorcontrib><description>Background: Alzheimer’s disease (AD) is a prevalent neurodegenerative disease. Treatments are necessary to target people at high risk for AD. Inflammation, particularly tumor necrosis factor alpha (TNFα), appears to be an important marker associated with the development of AD pathophysiology. Consuming a high-fat diet induces tissue expression of TNFα. Objective: This study investigates the relationship between nutrition, circulating inflammation, and cognition in African American women (age: M = 59.5 (±8.20) [42–73] years) at risk for developing AD. Methods: Participants were split into high-fat and low-fat groups based on total dietary fat consumption self-reported on the Lower Mississippi Delta Nutrition Intervention Research Initiative Food Frequency Questionnaire (Delta NIRI FFQ). Results: A high-fat diet was associated with increased blood serum TNFα (p = 0.02) compared to the low-fat diet. In addition, global cognition scores were 9.0% better in those who consumed a higher fat diet (p = 0.04). No significant differences across groups were noted for executive function, dual-tasking, and visuospatial performance. Conclusion: These results indicate that there may be multiple biological pathways involved in AD development, suggesting the need for more holistic approaches to mitigate AD-development risk.</description><identifier>ISSN: 2542-4823</identifier><identifier>EISSN: 2542-4823</identifier><identifier>DOI: 10.3233/ADR-200224</identifier><identifier>PMID: 33024941</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Research Report</subject><ispartof>JAD reports, 2020-08, Vol.4 (1), p.345-352</ispartof><rights>2020 – IOS Press and the authors. All rights reserved</rights><rights>2020 – IOS Press and the authors. All rights reserved.</rights><rights>2020 – IOS Press and the authors. All rights reserved 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c410t-7ffb1aabb34308610a819cb69e4c24d11b3ce1ec03acc5194f6593ea89676fe23</citedby><cites>FETCH-LOGICAL-c410t-7ffb1aabb34308610a819cb69e4c24d11b3ce1ec03acc5194f6593ea89676fe23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7504978/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7504978/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33024941$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jackson, Jordan M.</creatorcontrib><creatorcontrib>Bay, Allison A.</creatorcontrib><creatorcontrib>Barter, Jolie Denise</creatorcontrib><creatorcontrib>Ni, Liang</creatorcontrib><creatorcontrib>Caudle, William Michael</creatorcontrib><creatorcontrib>Serra, Monica C.</creatorcontrib><creatorcontrib>Wharton, Whitney</creatorcontrib><creatorcontrib>Hackney, Madeleine E.</creatorcontrib><title>The Role of Nutrition and Inflammation on Cognition in a High-Risk Group for Alzheimer’s Disease</title><title>JAD reports</title><addtitle>J Alzheimers Dis Rep</addtitle><description>Background: Alzheimer’s disease (AD) is a prevalent neurodegenerative disease. Treatments are necessary to target people at high risk for AD. Inflammation, particularly tumor necrosis factor alpha (TNFα), appears to be an important marker associated with the development of AD pathophysiology. Consuming a high-fat diet induces tissue expression of TNFα. Objective: This study investigates the relationship between nutrition, circulating inflammation, and cognition in African American women (age: M = 59.5 (±8.20) [42–73] years) at risk for developing AD. Methods: Participants were split into high-fat and low-fat groups based on total dietary fat consumption self-reported on the Lower Mississippi Delta Nutrition Intervention Research Initiative Food Frequency Questionnaire (Delta NIRI FFQ). Results: A high-fat diet was associated with increased blood serum TNFα (p = 0.02) compared to the low-fat diet. In addition, global cognition scores were 9.0% better in those who consumed a higher fat diet (p = 0.04). No significant differences across groups were noted for executive function, dual-tasking, and visuospatial performance. Conclusion: These results indicate that there may be multiple biological pathways involved in AD development, suggesting the need for more holistic approaches to mitigate AD-development risk.</description><subject>Research Report</subject><issn>2542-4823</issn><issn>2542-4823</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>AFRWT</sourceid><recordid>eNptkNtKAzEQhoMoVmpvfADJnSCs5rSnG6G02haKQqnXIZsm29TdTUl2Bb3yNXw9n8TV1VJBGJhh5pt_mB-AM4yuKKH0ejheBAQhQtgBOCEhIwFLCD3cq3tg4P0GIYQTEkWEHoMepYiwlOETkC3XCi5soaDV8L6pnamNraCoVnBW6UKUpfhutDGyedVNTQvAqcnXwcL4JzhxttlCbR0cFq9rZUrlPt7ePRwbr4RXp-BIi8KrwU_ug8e72-VoGswfJrPRcB5IhlEdxFpnWIgso4yiJMJIJDiVWZQqJglbYZxRqbCSiAopQ5wyHYUpVSJJozjSitA-uOl0t01WqpVUVe1EwbfOlMK9cCsM_zupzJrn9pnHIWJpnLQCl52AdNZ7p_RuFyP-ZTZvzead2S18vn9th_5a2wIXHeBFrvjGNq5qv_9P6hOItIfh</recordid><startdate>20200828</startdate><enddate>20200828</enddate><creator>Jackson, Jordan M.</creator><creator>Bay, Allison A.</creator><creator>Barter, Jolie Denise</creator><creator>Ni, Liang</creator><creator>Caudle, William Michael</creator><creator>Serra, Monica C.</creator><creator>Wharton, Whitney</creator><creator>Hackney, Madeleine E.</creator><general>SAGE Publications</general><general>IOS Press</general><scope>AFRWT</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20200828</creationdate><title>The Role of Nutrition and Inflammation on Cognition in a High-Risk Group for Alzheimer’s Disease</title><author>Jackson, Jordan M. ; Bay, Allison A. ; Barter, Jolie Denise ; Ni, Liang ; Caudle, William Michael ; Serra, Monica C. ; Wharton, Whitney ; Hackney, Madeleine E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c410t-7ffb1aabb34308610a819cb69e4c24d11b3ce1ec03acc5194f6593ea89676fe23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Research Report</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jackson, Jordan M.</creatorcontrib><creatorcontrib>Bay, Allison A.</creatorcontrib><creatorcontrib>Barter, Jolie Denise</creatorcontrib><creatorcontrib>Ni, Liang</creatorcontrib><creatorcontrib>Caudle, William Michael</creatorcontrib><creatorcontrib>Serra, Monica C.</creatorcontrib><creatorcontrib>Wharton, Whitney</creatorcontrib><creatorcontrib>Hackney, Madeleine E.</creatorcontrib><collection>SAGE Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>JAD reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jackson, Jordan M.</au><au>Bay, Allison A.</au><au>Barter, Jolie Denise</au><au>Ni, Liang</au><au>Caudle, William Michael</au><au>Serra, Monica C.</au><au>Wharton, Whitney</au><au>Hackney, Madeleine E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Role of Nutrition and Inflammation on Cognition in a High-Risk Group for Alzheimer’s Disease</atitle><jtitle>JAD reports</jtitle><addtitle>J Alzheimers Dis Rep</addtitle><date>2020-08-28</date><risdate>2020</risdate><volume>4</volume><issue>1</issue><spage>345</spage><epage>352</epage><pages>345-352</pages><issn>2542-4823</issn><eissn>2542-4823</eissn><abstract>Background: Alzheimer’s disease (AD) is a prevalent neurodegenerative disease. Treatments are necessary to target people at high risk for AD. Inflammation, particularly tumor necrosis factor alpha (TNFα), appears to be an important marker associated with the development of AD pathophysiology. Consuming a high-fat diet induces tissue expression of TNFα. Objective: This study investigates the relationship between nutrition, circulating inflammation, and cognition in African American women (age: M = 59.5 (±8.20) [42–73] years) at risk for developing AD. Methods: Participants were split into high-fat and low-fat groups based on total dietary fat consumption self-reported on the Lower Mississippi Delta Nutrition Intervention Research Initiative Food Frequency Questionnaire (Delta NIRI FFQ). Results: A high-fat diet was associated with increased blood serum TNFα (p = 0.02) compared to the low-fat diet. In addition, global cognition scores were 9.0% better in those who consumed a higher fat diet (p = 0.04). No significant differences across groups were noted for executive function, dual-tasking, and visuospatial performance. Conclusion: These results indicate that there may be multiple biological pathways involved in AD development, suggesting the need for more holistic approaches to mitigate AD-development risk.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>33024941</pmid><doi>10.3233/ADR-200224</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2542-4823
ispartof JAD reports, 2020-08, Vol.4 (1), p.345-352
issn 2542-4823
2542-4823
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7504978
source DOAJ Directory of Open Access Journals; PubMed Central Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central
subjects Research Report
title The Role of Nutrition and Inflammation on Cognition in a High-Risk Group for Alzheimer’s Disease
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-29T07%3A37%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-sage_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20Role%20of%20Nutrition%20and%20Inflammation%20on%20Cognition%20in%20a%20High-Risk%20Group%20for%20Alzheimer%E2%80%99s%20Disease&rft.jtitle=JAD%20reports&rft.au=Jackson,%20Jordan%20M.&rft.date=2020-08-28&rft.volume=4&rft.issue=1&rft.spage=345&rft.epage=352&rft.pages=345-352&rft.issn=2542-4823&rft.eissn=2542-4823&rft_id=info:doi/10.3233/ADR-200224&rft_dat=%3Csage_pubme%3E10.3233_ADR-200224%3C/sage_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/33024941&rft_sage_id=10.3233_ADR-200224&rfr_iscdi=true