Molecular determinants of release factor 2 for ArfA-mediated ribosome rescue

Translation termination in bacteria requires that the stop codon be recognized by release factor RF1 or RF2, leading to hydrolysis of the ester bond between the peptide and tRNA on the ribosome. As a consequence, normal termination cannot proceed if the translated mRNA lacks a stop codon. In Escheri...

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Veröffentlicht in:	The Journal of biological chemistry 2020-09, Vol.295 (38), p.13326-13337
Hauptverfasser:	Kurita, Daisuke, Abo, Tatsuhiko, Himeno, Hyouta
Format:	Artikel
Sprache:	eng
Schlagworte:	ArfA Escherichia coli - genetics Escherichia coli - metabolism Escherichia coli Proteins - genetics Escherichia coli Proteins - metabolism Peptide Chain Termination, Translational Peptide Termination Factors - genetics Peptide Termination Factors - metabolism peptidyl-tRNA hydrolysis protein synthesis Protein Synthesis and Degradation RF2 ribosome ribosome rescue Ribosomes - genetics Ribosomes - metabolism RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism stalled ribosome stop codon-independent termination translation translation control translation release factor
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