The Ca2+ channel CatSper is not activated by cAMP/PKA signaling but directly affected by chemicals used to probe the action of cAMP and PKA

The sperm-specific Ca2+ channel CatSper (cation channel of sperm) controls the influx of Ca2+ into the flagellum and, thereby, the swimming behavior of sperm. A hallmark of human CatSper is its polymodal activation by membrane voltage, intracellular pH, and oviductal hormones. Whether CatSper is als...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	The Journal of biological chemistry 2020-09, Vol.295 (38), p.13181-13193
Hauptverfasser:	Wang, Tao, Young, Samuel, Krenz, Henrike, Tüttelmann, Frank, Röpke, Albrecht, Krallmann, Claudia, Kliesch, Sabine, Zeng, Xu-Hui, Brenker, Christoph, Strünker, Timo
Format:	Artikel
Sprache:	eng
Schlagworte:	Ca2+ signaling calcium channel cAMP CatSper cyclic AMP (cAMP) ion channel pharmacology Signal Transduction sperm
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!