Combined Treatment of Sulfonyl Chromen-4-Ones (CHW09) and Ultraviolet-C (UVC) Enhances Proliferation Inhibition, Apoptosis, Oxidative Stress, and DNA Damage against Oral Cancer Cells

The sensitizing effect of chromone-derived compounds on UVC-induced proliferation inhibition has not been comprehensively investigated so far. The subject of this study was to examine the proliferation change of oral cancer cells while using the combined treatment of UVC (254 nm) with our previously...

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Veröffentlicht in:	International journal of molecular sciences 2020-09, Vol.21 (17), p.6443
Hauptverfasser:	Wang, Sheng-Chieh, Wang, Yen-Yun, Lin, Li-Ching, Chang, Meng-Yang, Yuan, Shyng-Shiou F, Tang, Jen-Yang, Chang, Hsueh-Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	Annexin V Apoptosis Cancer therapies Cell Cycle Cell growth Cell Movement Cell Proliferation Cell viability Chromones - chemistry Chromones - pharmacology Combined Modality Therapy Cytotoxicity Deoxyguanosine Deoxyribonucleic acid DNA DNA Damage Flow cytometry Humans Lung cancer Membrane potential Membrane Potential, Mitochondrial Mitochondria Mouth Neoplasms - drug therapy Mouth Neoplasms - metabolism Mouth Neoplasms - pathology Mouth Neoplasms - radiotherapy Oral cancer Oxidative Stress Poly (ADP-Ribose) Polymerase-1 - metabolism Poly(ADP-ribose) Poly(ADP-ribose) polymerase Reactive oxygen species Reactive Oxygen Species - metabolism Ribose Tumor Cells, Cultured Ultraviolet Rays Western blotting
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