Δ9-Tetrahydrocannabinol Prevents Mortality from Acute Respiratory Distress Syndrome through the Induction of Apoptosis in Immune Cells, Leading to Cytokine Storm Suppression

Acute Respiratory Distress Syndrome (ARDS) causes up to 40% mortality in humans and is difficult to treat. ARDS is also one of the major triggers of mortality associated with coronavirus-induced disease (COVID-19). We used a mouse model of ARDS induced by Staphylococcal enterotoxin B (SEB), which tr...

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Veröffentlicht in:	International journal of molecular sciences 2020-08, Vol.21 (17), p.6244
Hauptverfasser:	Mohammed, Amira, F K Alghetaa, Hasan, Miranda, Kathryn, Wilson, Kiesha, P Singh, Narendra, Cai, Guoshuai, Putluri, Nagireddy, Nagarkatti, Prakash, Nagarkatti, Mitzi
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Alveoli Animals Apoptosis Apoptosis - drug effects Betacoronavirus - physiology Bronchoalveolar Lavage Fluid - immunology Bronchus Cannabinoid Receptor Agonists - therapeutic use Cannabinoid receptors Cannabinoids Carnitine Chemokines Coronavirus Infections - drug therapy Coronavirus Infections - mortality Coronavirus Infections - virology Coronaviruses COVID-19 Cytochrome Cytokine storm Cytokines Cytokines - immunology Dronabinol - therapeutic use Electron transport Enterotoxins - adverse effects Female Gene expression Health services Humans Immune system Inflammation Laboratories Lung - immunology Lung - virology Lungs Lymphocytes Lysine Male Metabolism Metabolites Metabolomics Methionine Mice Mice, Inbred C3H MicroRNAs - genetics Middle Aged Mitochondria Mortality Neutrophils Pandemics Pneumonia - drug therapy Pneumonia - virology Pneumonia, Viral - drug therapy Pneumonia, Viral - mortality Pneumonia, Viral - virology Proteins Regulation Respiration Respiratory distress syndrome Respiratory Distress Syndrome - drug therapy Respiratory Distress Syndrome - mortality Respiratory Distress Syndrome - virology SARS-CoV-2 Signal Transduction - drug effects Staphylococcal enterotoxin B Storm suppression Survival T cell receptors Tetrahydrocannabinol THC Transcriptomics
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