Targeting Chemosensory Ion Channels in Peripheral Swallowing-Related Regions for the Management of Oropharyngeal Dysphagia
Oropharyngeal dysphagia, or difficulty in swallowing, is a major health problem that can lead to serious complications, such as pulmonary aspiration, malnutrition, dehydration, and pneumonia. The current clinical management of oropharyngeal dysphagia mainly focuses on compensatory strategies and swa...
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| Veröffentlicht in: | International journal of molecular sciences 2020-08, Vol.21 (17), p.6214 |
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| creator | Hossain, Mohammad Zakir Ando, Hiroshi Unno, Shumpei Kitagawa, Junichi |
| description | Oropharyngeal dysphagia, or difficulty in swallowing, is a major health problem that can lead to serious complications, such as pulmonary aspiration, malnutrition, dehydration, and pneumonia. The current clinical management of oropharyngeal dysphagia mainly focuses on compensatory strategies and swallowing exercises/maneuvers; however, studies have suggested their limited effectiveness for recovering swallowing physiology and for promoting neuroplasticity in swallowing-related neuronal networks. Several new and innovative strategies based on neurostimulation in peripheral and cortical swallowing-related regions have been investigated, and appear promising for the management of oropharyngeal dysphagia. The peripheral chemical neurostimulation strategy is one of the innovative strategies, and targets chemosensory ion channels expressed in peripheral swallowing-related regions. A considerable number of animal and human studies, including randomized clinical trials in patients with oropharyngeal dysphagia, have reported improvements in the efficacy, safety, and physiology of swallowing using this strategy. There is also evidence that neuroplasticity is promoted in swallowing-related neuronal networks with this strategy. The targeting of chemosensory ion channels in peripheral swallowing-related regions may therefore be a promising pharmacological treatment strategy for the management of oropharyngeal dysphagia. In this review, we focus on this strategy, including its possible neurophysiological and molecular mechanisms. |
| doi_str_mv | 10.3390/ijms21176214 |
| format | Article |
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The current clinical management of oropharyngeal dysphagia mainly focuses on compensatory strategies and swallowing exercises/maneuvers; however, studies have suggested their limited effectiveness for recovering swallowing physiology and for promoting neuroplasticity in swallowing-related neuronal networks. Several new and innovative strategies based on neurostimulation in peripheral and cortical swallowing-related regions have been investigated, and appear promising for the management of oropharyngeal dysphagia. The peripheral chemical neurostimulation strategy is one of the innovative strategies, and targets chemosensory ion channels expressed in peripheral swallowing-related regions. A considerable number of animal and human studies, including randomized clinical trials in patients with oropharyngeal dysphagia, have reported improvements in the efficacy, safety, and physiology of swallowing using this strategy. There is also evidence that neuroplasticity is promoted in swallowing-related neuronal networks with this strategy. The targeting of chemosensory ion channels in peripheral swallowing-related regions may therefore be a promising pharmacological treatment strategy for the management of oropharyngeal dysphagia. In this review, we focus on this strategy, including its possible neurophysiological and molecular mechanisms.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms21176214</identifier><identifier>PMID: 32867366</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Animals ; Capsaicin - pharmacology ; Capsaicin - therapeutic use ; Chemoreception ; Citric Acid - pharmacology ; Citric Acid - therapeutic use ; Clinical medicine ; Clinical trials ; Deglutition Disorders - drug therapy ; Deglutition Disorders - metabolism ; Dehydration ; Dementia ; Disease ; Drug therapy ; Dysphagia ; Esophagus ; Humans ; Ion channels ; Ion Channels - antagonists & inhibitors ; Ion Channels - metabolism ; Larynx ; Malnutrition ; Maneuvers ; Menthol - pharmacology ; Menthol - therapeutic use ; Molecular modelling ; Molecular Targeted Therapy ; Neural networks ; Neuronal Plasticity ; Neuroplasticity ; Older people ; Physiology ; Pneumonia ; Randomized Controlled Trials as Topic ; Review ; Sensory System Agents - pharmacology ; Sensory System Agents - therapeutic use ; Strategy ; Stroke ; Swallowing ; Transcranial magnetic stimulation</subject><ispartof>International journal of molecular sciences, 2020-08, Vol.21 (17), p.6214</ispartof><rights>2020. 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The current clinical management of oropharyngeal dysphagia mainly focuses on compensatory strategies and swallowing exercises/maneuvers; however, studies have suggested their limited effectiveness for recovering swallowing physiology and for promoting neuroplasticity in swallowing-related neuronal networks. Several new and innovative strategies based on neurostimulation in peripheral and cortical swallowing-related regions have been investigated, and appear promising for the management of oropharyngeal dysphagia. The peripheral chemical neurostimulation strategy is one of the innovative strategies, and targets chemosensory ion channels expressed in peripheral swallowing-related regions. A considerable number of animal and human studies, including randomized clinical trials in patients with oropharyngeal dysphagia, have reported improvements in the efficacy, safety, and physiology of swallowing using this strategy. There is also evidence that neuroplasticity is promoted in swallowing-related neuronal networks with this strategy. The targeting of chemosensory ion channels in peripheral swallowing-related regions may therefore be a promising pharmacological treatment strategy for the management of oropharyngeal dysphagia. 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The current clinical management of oropharyngeal dysphagia mainly focuses on compensatory strategies and swallowing exercises/maneuvers; however, studies have suggested their limited effectiveness for recovering swallowing physiology and for promoting neuroplasticity in swallowing-related neuronal networks. Several new and innovative strategies based on neurostimulation in peripheral and cortical swallowing-related regions have been investigated, and appear promising for the management of oropharyngeal dysphagia. The peripheral chemical neurostimulation strategy is one of the innovative strategies, and targets chemosensory ion channels expressed in peripheral swallowing-related regions. A considerable number of animal and human studies, including randomized clinical trials in patients with oropharyngeal dysphagia, have reported improvements in the efficacy, safety, and physiology of swallowing using this strategy. There is also evidence that neuroplasticity is promoted in swallowing-related neuronal networks with this strategy. The targeting of chemosensory ion channels in peripheral swallowing-related regions may therefore be a promising pharmacological treatment strategy for the management of oropharyngeal dysphagia. In this review, we focus on this strategy, including its possible neurophysiological and molecular mechanisms.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>32867366</pmid><doi>10.3390/ijms21176214</doi><orcidid>https://orcid.org/0000-0001-6471-9960</orcidid><orcidid>https://orcid.org/0000-0001-8526-7967</orcidid><orcidid>https://orcid.org/0000-0002-6621-8737</orcidid><orcidid>https://orcid.org/0000-0002-3720-8839</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Animals Capsaicin - pharmacology Capsaicin - therapeutic use Chemoreception Citric Acid - pharmacology Citric Acid - therapeutic use Clinical medicine Clinical trials Deglutition Disorders - drug therapy Deglutition Disorders - metabolism Dehydration Dementia Disease Drug therapy Dysphagia Esophagus Humans Ion channels Ion Channels - antagonists & inhibitors Ion Channels - metabolism Larynx Malnutrition Maneuvers Menthol - pharmacology Menthol - therapeutic use Molecular modelling Molecular Targeted Therapy Neural networks Neuronal Plasticity Neuroplasticity Older people Physiology Pneumonia Randomized Controlled Trials as Topic Review Sensory System Agents - pharmacology Sensory System Agents - therapeutic use Strategy Stroke Swallowing Transcranial magnetic stimulation |
| title | Targeting Chemosensory Ion Channels in Peripheral Swallowing-Related Regions for the Management of Oropharyngeal Dysphagia |
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