Cachexia: pathophysiology and ghrelin liposomes for nose-to-brain delivery

Cachexia, a severe multifactorial condition that is underestimated and unrecognized in patients, is characterized by continuous muscle mass loss that leads to progressive functional impairment, while nutritional support cannot completely reverse this clinical condition. There is a strong need for mo...

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Veröffentlicht in:	International journal of molecular sciences 2020-08, Vol.21 (17), p.1-16
Hauptverfasser:	T. de Barros, Cecilia, Rios, Alessandra C., Alves, Thaís F. R., Batain, Fernando, Crescencio, Kessi M. M., Lopes, Laura J., Zielinska, Aleksandra, Severino, Patricia, G. Mazzola, Priscila, Souto, Eliana B., Chaud, Marco V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intranasal Animals Apoptosis Appetite Bioavailability Biotecnologia Médica Blood-brain barrier Blood-Brain Barrier - metabolism Cachexia Cachexia - drug therapy Cachexia - etiology Catabolism Catecholamines Central nervous system Chronic illnesses Chronic obstructive pulmonary disease Ciências Médicas Cytokines Drug delivery systems Enzymes Ghrelin Ghrelin - administration & dosage Ghrelin - metabolism Ghrelin - therapeutic use Humans Infectious diseases Inflammation Liposomes Liposomes - metabolism Low income groups Metabolism Mortality Muscles Musculoskeletal system Nervous system Nose Patients Peptides Physiological effects Public health Quality of life Review Science & Technology Sepsis Tumor necrosis factor-TNF
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