Applications of Bionano Sensor for Extracellular Vesicles Analysis
Recently, extracellular vesicles (EVs) and their contents have been revealed to play crucial roles in the intrinsic intercellular communications and have received extensive attention as next-generation biomarkers for diagnosis of diseases such as cancers. However, due to the structural nature of the...
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| Veröffentlicht in: | Materials 2020-08, Vol.13 (17), p.3677 |
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| creator | Choi, Jin-Ha Lee, Jin-Ho Choi, Jeong-Woo |
| description | Recently, extracellular vesicles (EVs) and their contents have been revealed to play crucial roles in the intrinsic intercellular communications and have received extensive attention as next-generation biomarkers for diagnosis of diseases such as cancers. However, due to the structural nature of the EVs, the precise isolation and characterization are extremely challenging. To this end, tremendous efforts have been made to develop bionano sensors for the precise and sensitive characterization of EVs from a complex biologic fluid. In this review, we will provide a detailed discussion of recently developed bionano sensors in which EVs analysis applications were achieved, typically in optical and electrochemical methods. We believe that the topics discussed in this review will be useful to provide a concise guideline in the development of bionano sensors for EVs monitoring in the future. The development of a novel strategy to monitor various bio/chemical materials from EVs will provide promising information to understand cellular activities in a more precise manner and accelerates research on both cancer and cell-based therapy. |
| doi_str_mv | 10.3390/ma13173677 |
| format | Article |
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However, due to the structural nature of the EVs, the precise isolation and characterization are extremely challenging. To this end, tremendous efforts have been made to develop bionano sensors for the precise and sensitive characterization of EVs from a complex biologic fluid. In this review, we will provide a detailed discussion of recently developed bionano sensors in which EVs analysis applications were achieved, typically in optical and electrochemical methods. We believe that the topics discussed in this review will be useful to provide a concise guideline in the development of bionano sensors for EVs monitoring in the future. The development of a novel strategy to monitor various bio/chemical materials from EVs will provide promising information to understand cellular activities in a more precise manner and accelerates research on both cancer and cell-based therapy.</description><identifier>ISSN: 1996-1944</identifier><identifier>EISSN: 1996-1944</identifier><identifier>DOI: 10.3390/ma13173677</identifier><identifier>PMID: 32825537</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Biomarkers ; Biosensors ; Cancer ; Cell adhesion & migration ; Extracellular vesicles ; Heat shock proteins ; Nanomaterials ; Nanotechnology ; Nanowires ; Optical properties ; Ovarian cancer ; Peptides ; Review ; Sensors ; Vesicles ; Zinc oxides</subject><ispartof>Materials, 2020-08, Vol.13 (17), p.3677</ispartof><rights>2020. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). 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The development of a novel strategy to monitor various bio/chemical materials from EVs will provide promising information to understand cellular activities in a more precise manner and accelerates research on both cancer and cell-based therapy.</description><subject>Biomarkers</subject><subject>Biosensors</subject><subject>Cancer</subject><subject>Cell adhesion & migration</subject><subject>Extracellular vesicles</subject><subject>Heat shock proteins</subject><subject>Nanomaterials</subject><subject>Nanotechnology</subject><subject>Nanowires</subject><subject>Optical properties</subject><subject>Ovarian cancer</subject><subject>Peptides</subject><subject>Review</subject><subject>Sensors</subject><subject>Vesicles</subject><subject>Zinc oxides</subject><issn>1996-1944</issn><issn>1996-1944</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdkV1LwzAYhYMobszd-AOk4I0I1aRJm-RG2Mb8gIEXftyGNEs0o21qsor792Zu6jQQ8kIeznsOB4BjBC8w5vCylggjigtK90AfcV6kiBOyvzP3wDCEBYwHY8Qyfgh6OGNZnmPaB-NR21ZWyaV1TUicScZxkI1LHnQTnE9MvNOPpZdKV1VXSZ8862BVpUMyamS1CjYcgQMjq6CH23cAnq6nj5PbdHZ_czcZzVJFYLFMSVkgKNkc4qyQRClCjIRac2YoMaWiuiSYKagKaFBOEdUaUcVwBiWHkGcED8DVRrftylrPlW6irUq03tbSr4STVvz9aeyreHHvguYxOeFR4Gwr4N1bp8NS1Dasc8lGuy6IuKPAnDMCI3r6D124zsfAXxTN1pIsUucbSnkXgtfmxwyCYt2O-G0nwie79n_Q7y7wJyz9ib4</recordid><startdate>20200821</startdate><enddate>20200821</enddate><creator>Choi, Jin-Ha</creator><creator>Lee, Jin-Ho</creator><creator>Choi, Jeong-Woo</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>KB.</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-5877-0222</orcidid><orcidid>https://orcid.org/0000-0002-1632-9586</orcidid></search><sort><creationdate>20200821</creationdate><title>Applications of Bionano Sensor for Extracellular Vesicles Analysis</title><author>Choi, Jin-Ha ; 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| subjects | Biomarkers Biosensors Cancer Cell adhesion & migration Extracellular vesicles Heat shock proteins Nanomaterials Nanotechnology Nanowires Optical properties Ovarian cancer Peptides Review Sensors Vesicles Zinc oxides |
| title | Applications of Bionano Sensor for Extracellular Vesicles Analysis |
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