Pro- and anti-apoptotic dual functions of the C5a receptor: involvement of regulator of G protein signaling 3 and extracellular signal-regulated kinase

When apoptosis is initiated by manganese (II) loading, hyperthermia or thapsigargin treatment, human HL-60 and AsPC-1 cells initiate de novo synthesis of the C5a receptor (C5aR) and generation of its ligand, the ribosomal protein S19 (RP S19) homodimer. The ligand–receptor interaction, in an autocri...

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Veröffentlicht in:	Laboratory investigation 2009-06, Vol.89 (6), p.676-694
Hauptverfasser:	Nishiura, Hiroshi, Nonaka, Hideo, Revollo, Ivette S, Semba, Umeko, Li, Ying, Ota, Yoshihiko, Irie, Atsushi, Harada, Kumiko, Kehrl, John H, Yamamoto, Tetsuro
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals apoptosis Apoptosis - physiology Biological and medical sciences Biotechnology C5a C5a receptor Cell Line, Tumor Chemotaxis, Leukocyte extracellular signal-regulated kinase Extracellular Signal-Regulated MAP Kinases - physiology Female Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Neoplastic GTP-Binding Proteins - physiology GTPase-Activating Proteins - physiology Humans Investigative techniques, diagnostic techniques (general aspects) Laboratory Medicine Medical sciences Medicine Medicine & Public Health Mice Molecular Sequence Data Neoplasm Transplantation Pathology Phosphorylation Protein Binding Protein Multimerization Receptor, Anaphylatoxin C5a - agonists Receptor, Anaphylatoxin C5a - physiology regulator of G protein signaling 3 research-article RGS Proteins ribosomal protein S19 Ribosomal Proteins - metabolism Signal Transduction - physiology
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