Obesity-related hypoxia via miR-128 decreases insulin-receptor expression in human and mouse adipose tissue promoting systemic insulin resistance

Insulin resistance in visceral adipose tissue (VAT), skeletal muscle and liver is a prominent feature of most patients with obesity. How this association arises remains poorly understood. The objective of this study was to demonstrate that the decrease in insulin receptor (INSR) expression and insul...

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Veröffentlicht in:	EBioMedicine 2020-09, Vol.59, p.102912-102912, Article 102912
Hauptverfasser:	Arcidiacono, Biagio, Chiefari, Eusebio, Foryst-Ludwig, Anna, Currò, Giuseppe, Navarra, Giuseppe, Brunetti, Francesco S., Mirabelli, Maria, Corigliano, Domenica M., Kintscher, Ulrich, Britti, Domenico, Mollace, Vincenzo, Foti, Daniela P., Goldfine, Ira D., Brunetti, Antonio
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose-tissue dysfunction Hypoxia Insulin receptor Insulin resistance miRNA mRNA decay Obesity Research Paper
Online-Zugang:	Volltext
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