Functional Interplay between Histone H2B ADP-Ribosylation and Phosphorylation Controls Adipogenesis

Although ADP-ribosylation of histones by PARP-1 has been linked to genotoxic stress responses, its role in physiological processes and gene expression has remained elusive. We found that NAD+-dependent ADP-ribosylation of histone H2B-Glu35 by small nucleolar RNA (snoRNA)-activated PARP-1 inhibits AM...

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Veröffentlicht in:	Molecular cell 2020-09, Vol.79 (6), p.934-949.e14
Hauptverfasser:	Huang, Dan, Camacho, Cristel V., Setlem, Rohit, Ryu, Keun Woo, Parameswaran, Balaji, Gupta, Rana K., Kraus, W. Lee
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Diphosphate Ribose - genetics adipocytes Adipocytes - metabolism Adipocytes - pathology adipogenesis Adipogenesis - genetics ADP-ribosylation ADP-Ribosylation - genetics Animals catalytic activity Cell Line differentiation DNA Damage - genetics gene expression Gene Expression Regulation, Developmental - genetics genetic models histones Histones - genetics Mice mutagens obesity PARP-1 phosphorylation Phosphorylation - genetics Poly (ADP-Ribose) Polymerase-1 - genetics proliferation proteomics RNA RNA, Small Nucleolar - genetics snoRNA
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