Complement C3 vs C5 inhibition in severe COVID-19: Early clinical findings reveal differential biological efficacy

Growing clinical evidence has implicated complement as a pivotal driver of COVID-19 immunopathology. Deregulated complement activation may fuel cytokine-driven hyper-inflammation, thrombotic microangiopathy and NET-driven immunothrombosis, thereby leading to multi-organ failure. Complement therapeut...

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Veröffentlicht in:	Clinical immunology (Orlando, Fla.) Fla.), 2020-11, Vol.220, p.108598-108598, Article 108598
Hauptverfasser:	Mastellos, Dimitrios C., Pires da Silva, Bruno G.P., Fonseca, Benedito A.L., Fonseca, Natasha P., Auxiliadora-Martins, Maria, Mastaglio, Sara, Ruggeri, Annalisa, Sironi, Marina, Radermacher, Peter, Chrysanthopoulou, Akrivi, Skendros, Panagiotis, Ritis, Konstantinos, Manfra, Ilenia, Iacobelli, Simona, Huber-Lang, Markus, Nilsson, Bo, Yancopoulou, Despina, Connolly, E. Sander, Garlanda, Cecilia, Ciceri, Fabio, Risitano, Antonio M., Calado, Rodrigo T., Lambris, John D.
Format:	Artikel
Sprache:	eng
Schlagworte:	AMY-101 Antibodies, Monoclonal, Humanized - therapeutic use Betacoronavirus - pathogenicity Biomarkers Biomarkers - blood C-Reactive Protein - metabolism C3 inhibition C5 blockade Cohort Studies Complement Activation - drug effects Complement C3 - antagonists & inhibitors Complement C3 - genetics Complement C3 - immunology Complement C5 - antagonists & inhibitors Complement C5 - genetics Complement C5 - immunology Complement Inactivating Agents - therapeutic use Coronavirus Infections - complications Coronavirus Infections - drug therapy Coronavirus Infections - immunology Coronavirus Infections - virology COVID-19 Drug efficacy Eculizumab Extracellular Traps - drug effects Female Gene Expression Humans Immunologic Factors - therapeutic use Interleukin-6 - metabolism Male Middle Aged Neutrophils - drug effects Neutrophils - immunology Neutrophils - virology Pandemics Peptides, Cyclic - therapeutic use Pneumonia, Viral - complications Pneumonia, Viral - drug therapy Pneumonia, Viral - immunology Pneumonia, Viral - virology Respiratory Distress Syndrome - complications Respiratory Distress Syndrome - drug therapy Respiratory Distress Syndrome - immunology Respiratory Distress Syndrome - virology SARS-CoV-2 Severity of Illness Index Thromboinflammation
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