Next-Generation Total Synthesis of Vancomycin

A next-generation total synthesis of vancomycin aglycon is detailed that was achieved in 17 steps (longest linear sequence, LLS) from the constituent amino acid subunits with kinetically controlled diastereoselective introduction of all three elements of atropisomerism. In addition to new syntheses...

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Veröffentlicht in:	Journal of the American Chemical Society 2020-09, Vol.142 (37), p.16039-16050
Hauptverfasser:	Moore, Maxwell J, Qu, Shiwei, Tan, Ceheng, Cai, Yu, Mogi, Yuzo, Jamin Keith, D, Boger, Dale L
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Crystallography, X-Ray Models, Molecular Molecular Structure Stereoisomerism Vancomycin - chemical synthesis Vancomycin - chemistry
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