Glucose-6-Phosphate Dehydrogenase Is Not Essential for K-Ras-Driven Tumor Growth or Metastasis

The enzyme glucose-6-phosphate dehydrogenase (G6PD) is a major contributor to NADPH production and redox homeostasis and its expression is upregulated and correlated with negative patient outcomes in multiple human cancer types. Despite these associations, whether G6PD is essential for tumor initiat...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2020-09, Vol.80 (18), p.3820-3829
Hauptverfasser:	Ghergurovich, Jonathan M, Esposito, Mark, Chen, Zihong, Wang, Joshua Z, Bhatt, Vrushank, Lan, Taijin, White, Eileen, Kang, Yibin, Guo, Jessie Yanxiang, Rabinowitz, Joshua D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carcinoma, Non-Small-Cell Lung - genetics Cell Line, Tumor Cell Proliferation Colonic Neoplasms - enzymology Colonic Neoplasms - genetics Colonic Neoplasms - pathology Disease Models, Animal Female Gene Knockdown Techniques Genes, ras - physiology Glucosephosphate Dehydrogenase - genetics Glucosephosphate Dehydrogenase - physiology HCT116 Cells Humans Lung Neoplasms - enzymology Lung Neoplasms - genetics Lung Neoplasms - secondary Mice Mice, Nude Neoplasm Transplantation Neoplastic Cells, Circulating Oxidative Stress Triple Negative Breast Neoplasms - enzymology Triple Negative Breast Neoplasms - genetics Triple Negative Breast Neoplasms - pathology
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