Frequency and characteristics of MRI-negative myelitis associated with MOG autoantibodies
Background: Myelitis accompanied by a negative spinal cord MRI may lead to diagnostic uncertainty. Objective and Methods: We retrospectively investigated the frequency of negative spinal cord MRI (performed
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| Veröffentlicht in: | Multiple sclerosis 2021-02, Vol.27 (2), p.303-308 |
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| container_title | Multiple sclerosis |
| container_volume | 27 |
| creator | Sechi, Elia Krecke, Karl N Pittock, Sean J Dubey, Divyanshu Lopez-Chiriboga, A Sebastian Kunchok, Amy Weinshenker, Brian G Zalewski, Nicholas L Flanagan, Eoin P |
| description | Background:
Myelitis accompanied by a negative spinal cord MRI may lead to diagnostic uncertainty.
Objective and Methods:
We retrospectively investigated the frequency of negative spinal cord MRI (performed |
| doi_str_mv | 10.1177/1352458520907900 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7500857</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_1352458520907900</sage_id><sourcerecordid>2479663374</sourcerecordid><originalsourceid>FETCH-LOGICAL-c429t-9653199635285cb87cec381fa358b1348024a13b0f1df11675e0956af49643743</originalsourceid><addsrcrecordid>eNp1UU1LAzEUDKJord49ScDz6ssm2WwughS_QBFED55CNpttI-1Gk7TSf--WrfUDPL0HM29mmIfQEYFTQoQ4I5TnjJc8BwlCAmyhAWFCZCAFbHd7B2crfA_tx_gKAEJQvov2aE6ACigH6OUq2Pe5bc0S67bGZqKDNskGF5MzEfsG3z_eZq0d6-QWFs-WduqSi1jH6I3Tydb4w6UJvn-4xnqevG6Tq3ztbDxAO42eRnu4nkP0fHX5NLrJ7h6ub0cXd5lhuUyZLDglUhZd1JKbqhTGGlqSRlNeVoSyEnKmCa2gIXVDSCG4BckL3TBZMCoYHaLzXvdtXs1sbWybgp6qt-BmOiyV1079Rlo3UWO_UIIDlFx0AidrgeC7KmJSr34e2i6zypmQRUF7G-hZJvgYg202DgTU6hnq7zO6k-OfyTYHX-13hKwnRD22367_Cn4ClASRWQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2479663374</pqid></control><display><type>article</type><title>Frequency and characteristics of MRI-negative myelitis associated with MOG autoantibodies</title><source>SAGE Complete A-Z List</source><creator>Sechi, Elia ; Krecke, Karl N ; Pittock, Sean J ; Dubey, Divyanshu ; Lopez-Chiriboga, A Sebastian ; Kunchok, Amy ; Weinshenker, Brian G ; Zalewski, Nicholas L ; Flanagan, Eoin P</creator><creatorcontrib>Sechi, Elia ; Krecke, Karl N ; Pittock, Sean J ; Dubey, Divyanshu ; Lopez-Chiriboga, A Sebastian ; Kunchok, Amy ; Weinshenker, Brian G ; Zalewski, Nicholas L ; Flanagan, Eoin P</creatorcontrib><description>Background:
Myelitis accompanied by a negative spinal cord MRI may lead to diagnostic uncertainty.
Objective and Methods:
We retrospectively investigated the frequency of negative spinal cord MRI (performed <6 weeks from onset) in Mayo Clinic patients with myelin oligodendrocyte glycoprotein (MOG)-IgG-associated myelitis (2000–2019).
Results:
The initial spinal cord MRI was negative in 7/73 (10%) patients, despite severe acute disability (median EDSS, 7 (range, 4.5–8)); myelitis symptoms/signs were frequent (paraparesis, neurogenic bladder, sensory level, Lhermitte’s phenomenon). Myelitis lesions became overt at follow-up MRI in three patients.
Conclusions:
A negative spinal cord MRI should not dissuade from MOG-IgG testing in patients with acute/subacute myelitis.</description><identifier>ISSN: 1352-4585</identifier><identifier>EISSN: 1477-0970</identifier><identifier>DOI: 10.1177/1352458520907900</identifier><identifier>PMID: 32103708</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Autoantibodies ; Immunoglobulin G ; Inflammatory diseases ; Magnetic resonance imaging ; Myelin ; Myelitis ; Oligodendrocyte-myelin glycoprotein ; Spinal cord</subject><ispartof>Multiple sclerosis, 2021-02, Vol.27 (2), p.303-308</ispartof><rights>The Author(s), 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c429t-9653199635285cb87cec381fa358b1348024a13b0f1df11675e0956af49643743</citedby><cites>FETCH-LOGICAL-c429t-9653199635285cb87cec381fa358b1348024a13b0f1df11675e0956af49643743</cites><orcidid>0000-0001-5653-5600 ; 0000-0002-6661-2910</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/1352458520907900$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/1352458520907900$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>230,314,776,780,881,21798,27901,27902,43597,43598</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32103708$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sechi, Elia</creatorcontrib><creatorcontrib>Krecke, Karl N</creatorcontrib><creatorcontrib>Pittock, Sean J</creatorcontrib><creatorcontrib>Dubey, Divyanshu</creatorcontrib><creatorcontrib>Lopez-Chiriboga, A Sebastian</creatorcontrib><creatorcontrib>Kunchok, Amy</creatorcontrib><creatorcontrib>Weinshenker, Brian G</creatorcontrib><creatorcontrib>Zalewski, Nicholas L</creatorcontrib><creatorcontrib>Flanagan, Eoin P</creatorcontrib><title>Frequency and characteristics of MRI-negative myelitis associated with MOG autoantibodies</title><title>Multiple sclerosis</title><addtitle>Mult Scler</addtitle><description>Background:
Myelitis accompanied by a negative spinal cord MRI may lead to diagnostic uncertainty.
Objective and Methods:
We retrospectively investigated the frequency of negative spinal cord MRI (performed <6 weeks from onset) in Mayo Clinic patients with myelin oligodendrocyte glycoprotein (MOG)-IgG-associated myelitis (2000–2019).
Results:
The initial spinal cord MRI was negative in 7/73 (10%) patients, despite severe acute disability (median EDSS, 7 (range, 4.5–8)); myelitis symptoms/signs were frequent (paraparesis, neurogenic bladder, sensory level, Lhermitte’s phenomenon). Myelitis lesions became overt at follow-up MRI in three patients.
Conclusions:
A negative spinal cord MRI should not dissuade from MOG-IgG testing in patients with acute/subacute myelitis.</description><subject>Autoantibodies</subject><subject>Immunoglobulin G</subject><subject>Inflammatory diseases</subject><subject>Magnetic resonance imaging</subject><subject>Myelin</subject><subject>Myelitis</subject><subject>Oligodendrocyte-myelin glycoprotein</subject><subject>Spinal cord</subject><issn>1352-4585</issn><issn>1477-0970</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp1UU1LAzEUDKJord49ScDz6ssm2WwughS_QBFED55CNpttI-1Gk7TSf--WrfUDPL0HM29mmIfQEYFTQoQ4I5TnjJc8BwlCAmyhAWFCZCAFbHd7B2crfA_tx_gKAEJQvov2aE6ACigH6OUq2Pe5bc0S67bGZqKDNskGF5MzEfsG3z_eZq0d6-QWFs-WduqSi1jH6I3Tydb4w6UJvn-4xnqevG6Tq3ztbDxAO42eRnu4nkP0fHX5NLrJ7h6ub0cXd5lhuUyZLDglUhZd1JKbqhTGGlqSRlNeVoSyEnKmCa2gIXVDSCG4BckL3TBZMCoYHaLzXvdtXs1sbWybgp6qt-BmOiyV1079Rlo3UWO_UIIDlFx0AidrgeC7KmJSr34e2i6zypmQRUF7G-hZJvgYg202DgTU6hnq7zO6k-OfyTYHX-13hKwnRD22367_Cn4ClASRWQ</recordid><startdate>20210201</startdate><enddate>20210201</enddate><creator>Sechi, Elia</creator><creator>Krecke, Karl N</creator><creator>Pittock, Sean J</creator><creator>Dubey, Divyanshu</creator><creator>Lopez-Chiriboga, A Sebastian</creator><creator>Kunchok, Amy</creator><creator>Weinshenker, Brian G</creator><creator>Zalewski, Nicholas L</creator><creator>Flanagan, Eoin P</creator><general>SAGE Publications</general><general>Sage Publications Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-5653-5600</orcidid><orcidid>https://orcid.org/0000-0002-6661-2910</orcidid></search><sort><creationdate>20210201</creationdate><title>Frequency and characteristics of MRI-negative myelitis associated with MOG autoantibodies</title><author>Sechi, Elia ; Krecke, Karl N ; Pittock, Sean J ; Dubey, Divyanshu ; Lopez-Chiriboga, A Sebastian ; Kunchok, Amy ; Weinshenker, Brian G ; Zalewski, Nicholas L ; Flanagan, Eoin P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c429t-9653199635285cb87cec381fa358b1348024a13b0f1df11675e0956af49643743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Autoantibodies</topic><topic>Immunoglobulin G</topic><topic>Inflammatory diseases</topic><topic>Magnetic resonance imaging</topic><topic>Myelin</topic><topic>Myelitis</topic><topic>Oligodendrocyte-myelin glycoprotein</topic><topic>Spinal cord</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sechi, Elia</creatorcontrib><creatorcontrib>Krecke, Karl N</creatorcontrib><creatorcontrib>Pittock, Sean J</creatorcontrib><creatorcontrib>Dubey, Divyanshu</creatorcontrib><creatorcontrib>Lopez-Chiriboga, A Sebastian</creatorcontrib><creatorcontrib>Kunchok, Amy</creatorcontrib><creatorcontrib>Weinshenker, Brian G</creatorcontrib><creatorcontrib>Zalewski, Nicholas L</creatorcontrib><creatorcontrib>Flanagan, Eoin P</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Multiple sclerosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sechi, Elia</au><au>Krecke, Karl N</au><au>Pittock, Sean J</au><au>Dubey, Divyanshu</au><au>Lopez-Chiriboga, A Sebastian</au><au>Kunchok, Amy</au><au>Weinshenker, Brian G</au><au>Zalewski, Nicholas L</au><au>Flanagan, Eoin P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Frequency and characteristics of MRI-negative myelitis associated with MOG autoantibodies</atitle><jtitle>Multiple sclerosis</jtitle><addtitle>Mult Scler</addtitle><date>2021-02-01</date><risdate>2021</risdate><volume>27</volume><issue>2</issue><spage>303</spage><epage>308</epage><pages>303-308</pages><issn>1352-4585</issn><eissn>1477-0970</eissn><abstract>Background:
Myelitis accompanied by a negative spinal cord MRI may lead to diagnostic uncertainty.
Objective and Methods:
We retrospectively investigated the frequency of negative spinal cord MRI (performed <6 weeks from onset) in Mayo Clinic patients with myelin oligodendrocyte glycoprotein (MOG)-IgG-associated myelitis (2000–2019).
Results:
The initial spinal cord MRI was negative in 7/73 (10%) patients, despite severe acute disability (median EDSS, 7 (range, 4.5–8)); myelitis symptoms/signs were frequent (paraparesis, neurogenic bladder, sensory level, Lhermitte’s phenomenon). Myelitis lesions became overt at follow-up MRI in three patients.
Conclusions:
A negative spinal cord MRI should not dissuade from MOG-IgG testing in patients with acute/subacute myelitis.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>32103708</pmid><doi>10.1177/1352458520907900</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0001-5653-5600</orcidid><orcidid>https://orcid.org/0000-0002-6661-2910</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Multiple sclerosis, 2021-02, Vol.27 (2), p.303-308 |
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| source | SAGE Complete A-Z List |
| subjects | Autoantibodies Immunoglobulin G Inflammatory diseases Magnetic resonance imaging Myelin Myelitis Oligodendrocyte-myelin glycoprotein Spinal cord |
| title | Frequency and characteristics of MRI-negative myelitis associated with MOG autoantibodies |
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