Genome-Wide Somatic Alterations in Multiple Myeloma Reveal a Superior Outcome Group

Multiple myeloma (MM) is accompanied by heterogeneous somatic alterations. The overall goal of this study was to describe the genomic landscape of myeloma using deep whole-genome sequencing (WGS) and develop a model that identifies patients with long survival. We analyzed deep WGS data from 183 newl...

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Veröffentlicht in:	Journal of clinical oncology 2020-09, Vol.38 (27), p.3107-3118
Hauptverfasser:	Samur, Mehmet Kemal, Aktas Samur, Anil, Fulciniti, Mariateresa, Szalat, Raphael, Han, Tessa, Shammas, Masood, Richardson, Paul, Magrangeas, Florence, Minvielle, Stephane, Corre, Jill, Moreau, Philippe, Thakurta, Anjan, Anderson, Kenneth C, Parmigiani, Giovanni, Avet-Loiseau, Hervé, Munshi, Nikhil C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biomarkers, Tumor - genetics Bortezomib - administration & dosage Cancer Combined Modality Therapy Dexamethasone DNA Mutational Analysis DNA, Neoplasm Female GTP Phosphohydrolases - genetics Humans INDEL Mutation Lenalidomide - administration & dosage Life Sciences Male Membrane Proteins - genetics Middle Aged Multiple Myeloma - genetics Multiple Myeloma - therapy ORIGINAL REPORTS Progression-Free Survival Stem Cell Transplantation Survival Rate Treatment Outcome Whole Genome Sequencing
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