Hepatitis C virus enhances Rubicon expression, leading to autophagy inhibition and intracellular innate immune activation

Autophagy, a degradation system, works to maintain cellular homeostasis. However, as the impact of Hepatitis C virus (HCV) infection on hepatocyte autophagy and its effect on HCV replication remain unclear, we examined them. HCV infection suppressed late-stage autophagy and increased Rubicon. siRNA-...

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Veröffentlicht in:	Scientific reports 2020-09, Vol.10 (1), p.15290, Article 15290
Hauptverfasser:	Shiode, Yuto, Hikita, Hayato, Tanaka, Satoshi, Shirai, Kumiko, Doi, Akira, Sakane, Sadatsugu, Kai, Yugo, Nakabori, Tasuku, Yamada, Ryoko, Kodama, Takahiro, Narumi, Ryohei, Sakamori, Ryotaro, Eguchi, Hidetoshi, Tomonaga, Takeshi, Tatsumi, Tomohide, Takehara, Tetsuo
Format:	Artikel
Sprache:	eng
Schlagworte:	692/4020 692/4020/4021 Animals Autophagy - immunology Autophagy-Related Proteins - immunology Cell Line, Tumor Cytoplasm - immunology Hepacivirus - immunology Hepatitis C, Chronic - immunology Hepatocytes - immunology Host-Pathogen Interactions - immunology Humanities and Social Sciences Humans Immunity, Innate - immunology Interferon Type I - immunology Mice multidisciplinary Replicon - immunology Science Science (multidisciplinary) Signal Transduction - immunology Virus Replication - immunology
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