Selective inhibition of anti‐MAG IgM autoantibody binding to myelin by an antigen‐specific glycopolymer

Anti‐myelin‐associated glycoprotein (MAG) neuropathy is a disabling autoimmune peripheral neuropathy that is caused by circulating monoclonal IgM autoantibodies directed against the human natural killer‐1 (HNK‐1) epitope. This carbohydrate epitope is highly expressed on adhesion molecules such as MA...

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Veröffentlicht in:	Journal of neurochemistry 2020-09, Vol.154 (5), p.486-501
Hauptverfasser:	Aliu, Butrint, Demeestere, Delphine, Seydoux, Emilie, Boucraut, José, Delmont, Emilien, Brodovitch, Alexandre, Oberholzer, Thomas, Attarian, Shahram, Théaudin, Marie, Tsouni, Pinelopi, Kuntzer, Thierry, Derfuss, Tobias, Steck, Andreas J., Ernst, Beat, Herrendorff, Ruben, Hänggi, Pascal
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Antibodies, Monoclonal - immunology Antigens antigen‐specific treatment anti‐MAG IgM autoantibodies Autoantibodies Autoantibodies - immunology Binding Biodegradability Biodegradation Blood Carbohydrates CD20 antigen Cognitive science demyelinating peripheral neuropathy Depletion Epitopes Glycopolymers Glycoproteins Glycoproteins - metabolism HIGHLIGHTED ARTICLE Humans Immunization Immunoglobulin M Immunoglobulin M - immunology Immunology Inflammation Intravenous administration Leukocytes (mononuclear) Leukocytes, Mononuclear - immunology Leukocytes, Mononuclear - metabolism monoclonal gammopathy of neurological significance Myelin Myelin Sheath - metabolism Myelin-associated glycoprotein Neuroscience Original Peripheral blood mononuclear cells Peripheral nerves Peripheral Nerves - immunology Peripheral Nervous System Diseases - immunology Peripheral neuropathy Pharmacodynamics Polymers
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