The Human Host‐Defense Peptide Cathelicidin LL‐37 is a Nanomolar Inhibitor of Amyloid Self‐Assembly of Islet Amyloid Polypeptide (IAPP)

Amyloid self‐assembly of islet amyloid polypeptide (IAPP) is linked to pancreatic inflammation, β‐cell degeneration, and the pathogenesis of type 2 diabetes (T2D). The multifunctional host‐defence peptides (HDPs) cathelicidins play crucial roles in inflammation. Here, we show that the antimicrobial...

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Veröffentlicht in:	Angewandte Chemie International Edition 2020-07, Vol.59 (31), p.12837-12841
Hauptverfasser:	Armiento, Valentina, Hille, Kathleen, Naltsas, Denise, Lin, Jennifer S., Barron, Annelise E., Kapurniotu, Aphrodite
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amylin Amyloid amyloids Antiinfectives and antibacterials Antimicrobial Cationic Peptides - metabolism Assembly Beta cells Cathelicidins Communication Communications Degeneration Diabetes mellitus (non-insulin dependent) Drug development Humans Immunomodulation inhibitors Islet Amyloid Polypeptide - chemistry Islet Amyloid Polypeptide - metabolism Pancreas Pathogenesis Peptide Fragments - metabolism Peptides Polypeptides Protein Binding protein interactions Protein Multimerization - drug effects self-assembly type 2 diabetes
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