Fluorogenic Bifunctional trans‐Cyclooctenes as Efficient Tools for Investigating Click‐to‐Release Kinetics

The inverse electron demand Diels–Alder pyridazine elimination reaction between tetrazines and allylic substituted trans‐cyclooctenes (TCOs) is a key player in bioorthogonal bond cleavage reactions. Determining the rate of elimination of alkylamine substrates has so far proven difficult. Here, we re...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Chemistry : a European journal 2020-08, Vol.26 (44), p.9900-9904
Hauptverfasser:	Geus, Mark A. R., Maurits, Elmer, Sarris, Alexi J. C., Hansen, Thomas, Kloet, Max S., Kamphorst, Kiki, Hoeve, Wolter, Robillard, Marc S., Pannwitz, Andrea, Bonnet, Sylvestre A., Codée, Jeroen D. C., Filippov, Dmitri V., Overkleeft, Herman S., Kasteren, Sander I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylamines bioorthogonal chemistry Chemistry Diels–Alder reactions fluorescent probes kinetics nitrogen heterocycles Rate constants Reaction kinetics Substrates
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!