Ex vivo blockade of PI3K gamma or delta signaling enhances the antitumor potency of adoptively transferred CD8+ T cells

Adoptive T cell transfer therapy induces objective responses in patients with advanced malignancies. Despite these results, some individuals do not respond due to the generation of terminally differentiated T cells during the expansion protocol. As the gamma and delta catalytic subunits in the PI3K...

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Veröffentlicht in:	European journal of immunology 2020-09, Vol.50 (9), p.1386-1399
Hauptverfasser:	Dwyer, Connor J., Arhontoulis, Dimitrios C., Rangel Rivera, Guillermo O, Knochelmann, Hannah M., Smith, Aubrey S., Wyatt, Megan M., Rubinstein, Mark P., Atkinson, Carl, Thaxton, Jessica E., Neskey, David M., Paulos, Chrystal M.
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase ACT Animals Antitumor activity Basic Cancer CAR Catalytic subunits CD8 antigen CD8-Positive T-Lymphocytes - transplantation Cell activation Cell differentiation Class I Phosphatidylinositol 3-Kinases - antagonists & inhibitors Class I Phosphatidylinositol 3-Kinases - drug effects Class Ib Phosphatidylinositol 3-Kinase - drug effects Class Ib Phosphatidylinositol 3-Kinase - metabolism Cytokines Heterocyclic Compounds, 4 or More Rings - pharmacology Humans Immunotherapy, Adoptive - methods Isoquinolines - pharmacology Leukocytes Lymphocytes Lymphocytes T Mice Phenotypes Phosphoinositide 3‐kinase Pyrazoles - pharmacology Pyrimidines - pharmacology Receptors, Chimeric Antigen T cells Tumor immunology Tumors
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